Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Anat Gafter-Gvili; Abigail Fraser; Mical Paul; Liat Vidal; Theresa A Lawrie; Marianne D van de Wetering; Leontien C M Kremer; Leonard Leibovici

doi:10.1002/14651858.CD004386.pub3

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Anat Gafter-Gvili, Abigail Fraser, Mical Paul, Liat Vidal, Theresa A Lawrie, Marianne D van de Wetering, Leontien C M Kremer, Leonard Leibovici

Research output: Contribution to journal › Article (Academic Journal) › peer-review

173 Citations (Scopus)

Abstract

Bacterial infections are a major cause of morbidity and mortality in patients who are neutropenic following chemotherapy for malignancy. Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality.

Original language	English
Pages (from-to)	CD004386
Journal	Cochrane Database of Systematic Reviews
Volume	1
DOIs	https://doi.org/10.1002/14651858.CD004386.pub3
Publication status	Published - 2012

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10.1002/14651858.CD004386.pub3

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CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G.
1/09/07 → 1/09/13
Project: Research

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title = "Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy",

abstract = "Bacterial infections are a major cause of morbidity and mortality in patients who are neutropenic following chemotherapy for malignancy. Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality.",

author = "Anat Gafter-Gvili and Abigail Fraser and Mical Paul and Liat Vidal and Lawrie, {Theresa A} and {van de Wetering}, {Marianne D} and Kremer, {Leontien C M} and Leonard Leibovici",

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doi = "10.1002/14651858.CD004386.pub3",

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Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy. / Gafter-Gvili, Anat; Fraser, Abigail; Paul, Mical; Vidal, Liat; Lawrie, Theresa A; van de Wetering, Marianne D; Kremer, Leontien C M; Leibovici, Leonard.

In: Cochrane Database of Systematic Reviews, Vol. 1, 2012, p. CD004386.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

AU - Gafter-Gvili, Anat

AU - Fraser, Abigail

AU - Paul, Mical

AU - Vidal, Liat

AU - Lawrie, Theresa A

AU - van de Wetering, Marianne D

AU - Kremer, Leontien C M

AU - Leibovici, Leonard

PY - 2012

Y1 - 2012

N2 - Bacterial infections are a major cause of morbidity and mortality in patients who are neutropenic following chemotherapy for malignancy. Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality.

AB - Bacterial infections are a major cause of morbidity and mortality in patients who are neutropenic following chemotherapy for malignancy. Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality.

U2 - 10.1002/14651858.CD004386.pub3

DO - 10.1002/14651858.CD004386.pub3

M3 - Article (Academic Journal)

C2 - 22258955

VL - 1

SP - CD004386

JO - Cochrane Database of Systematic Reviews

JF - Cochrane Database of Systematic Reviews

SN - 1469-493X

ER -

Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy

Abstract

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