Antibody-targeted drug delivery to injured arteries using layered double hydroxide nanoparticles

Zi Gu, Barbara Rolfe, Zhi-Ping Xu, Julie Campbell, GQM Lu, Anita C Thomas

Research output: Contribution to journalArticle (Academic Journal)peer-review

33 Citations (Scopus)

Abstract

Targeted local delivery of a nanoparticle-based, antibody-targeted, and low molecular weight heparin (LMWH) delivery system successfully reduces restenosis and thrombus formation in an animal model. An antibody recognizing cross-linked fibrin (XLF) D-dimer is successfully conjugated to layered double hydroxide nanoparticles. Use of the anti-XLF-conjugated LMWH-carrying layered double hydroxide nanoparticles shows successful targeting of the nanoparticles (red) to the injured artery wall (green), resulting in decreased neointimal thickening and thrombus formation.
Original languageEnglish
Pages (from-to)669-673
Number of pages5
JournalAdvanced Healthcare Materials
Volume1
Publication statusPublished - 2012

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