Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

CL Trotter, J McVernon, NJ Andrews, M Burrage, ME Ramsay

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Abstract

Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.
Translated title of the contributionAntibody to Haemophilus influenzae type b after routine and catch-up vaccination
Original languageEnglish
Pages (from-to)1523 - 1524
Number of pages2
JournalLancet
Volume361 (9368)
DOIs
Publication statusPublished - 3 May 2003

Bibliographical note

Publisher: Elsevier

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