Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

CL Trotter; J McVernon; NJ Andrews; M Burrage; ME Ramsay

doi:10.1016/S0140-6736(03)13172-8

Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

CL Trotter, J McVernon, NJ Andrews, M Burrage, ME Ramsay

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

60 Citations (Scopus)

Abstract

Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.

Translated title of the contribution	Antibody to Haemophilus influenzae type b after routine and catch-up vaccination
Original language	English
Pages (from-to)	1523 - 1524
Number of pages	2
Journal	Lancet
Volume	361 (9368)
DOIs	https://doi.org/10.1016/S0140-6736(03)13172-8
Publication status	Published - 3 May 2003

Bibliographical note

Publisher: Elsevier

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title = "Antibody to Haemophilus influenzae type b after routine and catch-up vaccination",

abstract = "Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.",

author = "CL Trotter and J McVernon and NJ Andrews and M Burrage and ME Ramsay",

note = "Publisher: Elsevier",

year = "2003",

month = may,

day = "3",

doi = "10.1016/S0140-6736(03)13172-8",

language = "English",

volume = "361 (9368)",

pages = "1523 -- 1524",

journal = "Lancet",

issn = "1474-547X",

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TY - JOUR

T1 - Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

AU - Trotter, CL

AU - McVernon, J

AU - Andrews, NJ

AU - Burrage, M

AU - Ramsay, ME

N1 - Publisher: Elsevier

PY - 2003/5/3

Y1 - 2003/5/3

N2 - Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.

AB - Since 1999, the number of cases of Haemophilus influenzae type b (Hib) disease in the UK has risen. We investigated the role of population immunity in this change by testing more than 2600 serum samples from children aged 1-15 years. After the introduction of the routine Hib conjugate vaccination programme for infants, median antibody titres rose significantly in 1-year-olds. Individuals who received their first dose of vaccine at age 1-4 years in the original catch-up campaign initially had much higher concentrations of antibody than those who had been immunised in infancy. A second catch-up campaign in children aged 6 months to 4 years should be highly effective in boosting immunity and reducing disease in the short term.

U2 - 10.1016/S0140-6736(03)13172-8

DO - 10.1016/S0140-6736(03)13172-8

M3 - Article (Academic Journal)

SN - 1474-547X

VL - 361 (9368)

SP - 1523

EP - 1524

JO - Lancet

JF - Lancet

ER -

Antibody to Haemophilus influenzae type b after routine and catch-up vaccination

Abstract

Bibliographical note

UN SDGs

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