Antidepressant-induced jitteriness/anxiety syndrome: systematic review

LI Sinclair, DM Christmas, SD Hood, JP Potokar, Robertson Andrea, Isaac Andrew, Srivastava Shrikant, DJ Nutt, S Davies

Research output: Contribution to journalArticle (Academic Journal)peer-review

138 Citations (Scopus)


Early worsening of anxiety, agitation and irritability are thought to be common among people commencing antidepressants, especially for anxiety disorders. This phenomenon, which may be termed jitteriness/anxiety syndrome, is cited as an explanation for early treatment failure and caution in using selective serotonin reuptake inhibitors (SSRIs). However, we believe that it is inconsistently defined and that robust evidence to support the phenomenon is lacking
Translated title of the contributionAntidepressant-induced jitteriness/anxiety syndrome: systematic review
Original languageEnglish
Pages (from-to)483 - 490
Number of pages8
JournalBritish Journal of Psychiatry
Issue number6
Publication statusPublished - Jun 2009


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