Antimicrobial and anticancer efficacy of antineoplastic agent capped gold nanoparticles

V. Selvaraj*, A. Nirmala Grace, M. Alagar, I. Hamerton

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Citations (Scopus)

Abstract

Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E-Coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.

Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalJournal of Biomedical Nanotechnology
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Antimicrobial and anticancer studies
  • Au@TG complex
  • Gold nanoparticles
  • Thioguanine

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