TY - JOUR
T1 - Antimicrobial and anticancer efficacy of antineoplastic agent capped gold nanoparticles
AU - Selvaraj, V.
AU - Nirmala Grace, A.
AU - Alagar, M.
AU - Hamerton, I.
PY - 2010/4
Y1 - 2010/4
N2 - Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E-Coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.
AB - Synthesis of thioguanine (TG)-capped Au nanoparticles (Au@TG) and their enhanced in vitro antimicrobial and anticancer efficacy against Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, E-Coli, Aspergillus fumigatus, Aspergillus niger and Hep2 cancer cell (Human epidermiod cell) have been reported. The nature of binding between 6-TG and the gold nanoparticles via complexation is investigated using ultraviolet-visible spectrum, cyclic voltammetry, transmission electron microscopy, fluorescence and Fourier transform infrared (FT-IR) spectroscopy. The present experimental studies suggests that Au@TG are more potential than TG towards antimicrobial and anticancer activities. Hence, gold nanoparticles have the potential to be used as effective carriers for anticancer drug.
KW - Antimicrobial and anticancer studies
KW - Au@TG complex
KW - Gold nanoparticles
KW - Thioguanine
UR - http://www.scopus.com/inward/record.url?scp=77955456908&partnerID=8YFLogxK
U2 - 10.1166/jbn.2010.1115
DO - 10.1166/jbn.2010.1115
M3 - Article (Academic Journal)
C2 - 20738066
AN - SCOPUS:77955456908
SN - 1550-7033
VL - 6
SP - 129
EP - 137
JO - Journal of Biomedical Nanotechnology
JF - Journal of Biomedical Nanotechnology
IS - 2
ER -
