Apathy in rapid eye movement sleep behaviour disorder is common and under-recognised

Thomas R Barber, Kinan Muhammed, Daniel Drew, Michael Lawton, Marie Crabbe, Michal Rolinski, Timothy Quinnell, Zenobia Zaiwalla, Yoav Ben-Shlomo, Masud Husain, Michele Tm Hu

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)
212 Downloads (Pure)

Abstract

BACKGROUND: Apathy is an important neuropsychiatric feature of Parkinson's disease (PD), which often emerges before the onset of motor symptoms. Patients with rapid eye movement sleep behaviour disorder (RBD) have a high probability of developing Parkinson's disease in future. Neuropsychiatric problems are common in RBD, but apathy has not previously been detailed in this key prodromal population.

METHODS: 88 patients with polysomnographically proven RBD, 65 patients with PD and 33 controls were assessed for apathy using the Lille Apathy Rating Scale (LARS). Cognition and depression were also quantified. The sensitivity of the Unified Parkinson's Disease Rating Scale screening questions for apathy and depression was calculated.

RESULTS: 46% of Patients with RBD were apathetic, compared with 31% of Parkinson's patients in our sample. Most RBD patients with depression were apathetic but more than half of apathetic patients were not depressed. The sensitivity of the single UPDRS screening question was only 33% for mild apathy and 50% for severe apathy.

CONCLUSIONS: Apathy is common in RBD and is underestimated by a single self-report question. Recognition of apathy as a distinct neuropsychiatric feature in RBD could aid targeted treatment interventions and might contribute to understanding of prodromal Parkinson's disease. This article is protected by copyright. All rights reserved.

Original languageEnglish
Pages (from-to)469-e32
Number of pages9
JournalEuropean Journal of Neurology
Volume25
Issue number3
Early online date14 Dec 2017
DOIs
Publication statusPublished - Mar 2018

Keywords

  • apathy
  • Parkinson's disease
  • prodromal
  • rapid eye movement sleep behaviour disorder

Fingerprint Dive into the research topics of 'Apathy in rapid eye movement sleep behaviour disorder is common and under-recognised'. Together they form a unique fingerprint.

Cite this