Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

A Okazaki, MB Avison

Research output: Contribution to journalArticle (Academic Journal)peer-review

51 Citations (Scopus)

Abstract

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.
Translated title of the contributionAph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia
Original languageEnglish
Pages (from-to)359 - 360
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume51 (1)
DOIs
Publication statusPublished - Jan 2007

Bibliographical note

Publisher: American Society of Medicine

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