Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

A Okazaki; MB Avison

doi:10.1128/AAC.00795-06

Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

A Okazaki
, MB Avison

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Article (Academic Journal) › peer-review

87 Citations (Scopus)

Abstract

We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

Translated title of the contribution	Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia
Original language	English
Pages (from-to)	359 - 360
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	51 (1)
DOIs	https://doi.org/10.1128/AAC.00795-06
Publication status	Published - Jan 2007

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Publisher: American Society of Medicine

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http://aac.asm.org/cgi/content/abstract/51/1/359

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title = "Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia",

abstract = "We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.",

author = "A Okazaki and MB Avison",

note = "Publisher: American Society of Medicine",

year = "2007",

month = jan,

doi = "10.1128/AAC.00795-06",

language = "English",

volume = "51 (1)",

pages = "359 -- 360",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "1098-6596",

publisher = "American Society for Microbiology",

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T1 - Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

AU - Okazaki, A

AU - Avison, MB

N1 - Publisher: American Society of Medicine

PY - 2007/1

Y1 - 2007/1

N2 - We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

AB - We report the characterization of an intrinsic, chromosomally carried aph(3')-IIc gene from Stenotrophomonas maltophilia clinical isolate K279a, encoding an aminoglycoside phosphotransferase enzyme that significantly increases MICs of kanamycin, neomycin, butirosin, and paromomycin when expressed in Escherichia coli. Disruption of aph(3')-IIc in K279a results in decreased MICs of these drugs.

U2 - 10.1128/AAC.00795-06

DO - 10.1128/AAC.00795-06

M3 - Article (Academic Journal)

SN - 1098-6596

VL - 51 (1)

SP - 359

EP - 360

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

Aph(3')-IIc, an aminoglycoside resistance determinant from Stenotrophomonas maltophilia

Abstract

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