Application of photon correlation spectroscopy as a technique for detecting culture contamination

R I JEPRAS, E A PERKINS, J RARITY, R J G CARR, D J CLARKE, T ATKINSON

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)

Abstract

The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.

Original languageEnglish
Pages (from-to)929-940
Number of pages12
JournalBiotechnology and Bioengineering
Volume38
Issue number8
DOIs
Publication statusPublished - 20 Oct 1991

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