Application of photon correlation spectroscopy as a technique for detecting culture contamination

R I  JEPRAS; E A  PERKINS; J  RARITY; R J G  CARR; D J  CLARKE; T  ATKINSON

doi:10.1002/bit.260380814

Application of photon correlation spectroscopy as a technique for detecting culture contamination

R I JEPRAS, E A PERKINS, J RARITY, R J G CARR, D J CLARKE, T ATKINSON

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Abstract

The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.

Original language	English
Pages (from-to)	929-940
Number of pages	12
Journal	Biotechnology and Bioengineering
Volume	38
Issue number	8
DOIs	https://doi.org/10.1002/bit.260380814
Publication status	Published - 20 Oct 1991

Research Groups and Themes

Photonics and Quantum

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title = "Application of photon correlation spectroscopy as a technique for detecting culture contamination",

abstract = "The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.",

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AU - JEPRAS, R I

AU - PERKINS, E A

AU - RARITY, J

AU - CARR, R J G

AU - CLARKE, D J

AU - ATKINSON, T

PY - 1991/10/20

Y1 - 1991/10/20

N2 - The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.

AB - The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydispersity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.

U2 - 10.1002/bit.260380814

DO - 10.1002/bit.260380814

M3 - Article (Academic Journal)

SN - 0006-3592

VL - 38

SP - 929

EP - 940

JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

IS - 8

ER -

Application of photon correlation spectroscopy as a technique for detecting culture contamination

Abstract

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