Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

Sergey Kasparov

doi:10.1016/j.cmet.2015.11.001

Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

Sergey Kasparov

Research output: Contribution to journal › Article (Academic Journal) › peer-review

19 Citations (Scopus)

347 Downloads (Pure)

Abstract

The role of lactate in the brain has been controversial. In this issue, Mächler et al. (2015) present data from in vivo experiments suggesting that there is a downward gradient of lactate in the brain. They provide a mechanistic basis for the proposed export of lactate from astrocytes to neurons.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Cell Metabolism
Volume	23
Issue number	1
Early online date	19 Nov 2015
DOIs	https://doi.org/10.1016/j.cmet.2015.11.001
Publication status	Published - 12 Jan 2016

Access to Document

10.1016/j.cmet.2015.11.001

Preview_CMetab_on_Machler_FINAL
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier (Cell) at http://www.sciencedirect.com/science/article/pii/S1550413115005689. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 285 KBLicence: CC BY-NC-ND

Handle.net

Persistent link

Exploring astrocytic orphan G-protein coupled receptors as potential targets for neuroprotective therapies
Kasparov, S. (Principal Investigator)
15/07/14 → 14/07/17
Project: Research
Dissection of the cellular mechanisms of functional MRI using targeted optogenetics
Kasparov, S. (Principal Investigator)
1/07/12 → 1/10/15
Project: Research

Cite this

@article{a6551dd7186b43f2926b54b303b51c19,

title = "Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?",

abstract = "The role of lactate in the brain has been controversial. In this issue, M{\"a}chler et al. (2015) present data from in vivo experiments suggesting that there is a downward gradient of lactate in the brain. They provide a mechanistic basis for the proposed export of lactate from astrocytes to neurons.",

author = "Sergey Kasparov",

year = "2016",

month = jan,

day = "12",

doi = "10.1016/j.cmet.2015.11.001",

language = "English",

volume = "23",

pages = "1--2",

journal = "Cell Metabolism",

issn = "1550-4131",