From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.
Bibliographical noteFunding Information:
We are grateful for Dr. Haruki Nishimura (UOEH) for his robust assessment of our manuscript. This article was supported by a Grant-in-Aid for Scientific Research (C) ( 21K06779 ) KAKENHI for M.Y. from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) , Japan; a Grant for Encouragement of Young Scientists for M.Y. from the University of Occupational and Environmental Health (UOEH) , Japan; an Overseas Research Grant for M.Y. from the Uehara Memorial Foundation, Japan ; a Grant-in-Aid for Scientific Research (B) (17H04027) KAKENHI for Y.U. from the MEXT, Japan; a Research Grant for Y.U. from The Salt Science Research Foundation (SSRF) (No. 2122), Japan; and United Kingdom Medical Research Council Grant MR/R010919/1 supporting B.C-C.
- Arginine vasopressin
- Circadian rhythm
- Energy balance
- HPA axis