Arginine vasopressin: Direct and indirect action on metabolism

Mitsuhiro Yoshimura; Becky L Conway-Campbell; Yoichi Ueta

doi:10.1016/j.peptides.2021.170555

Arginine vasopressin: Direct and indirect action on metabolism

Mitsuhiro Yoshimura^*
, Becky L Conway-Campbell
, Yoichi Ueta

^*Corresponding author for this work

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

53 Citations (Scopus)

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Abstract

From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.

Original language	English
Article number	170555
Number of pages	12
Journal	Peptides
Volume	142
Early online date	24 Apr 2021
DOIs	https://doi.org/10.1016/j.peptides.2021.170555
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
We are grateful for Dr. Haruki Nishimura (UOEH) for his robust assessment of our manuscript. This article was supported by a Grant-in-Aid for Scientific Research (C) ( 21K06779 ) KAKENHI for M.Y. from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) , Japan; a Grant for Encouragement of Young Scientists for M.Y. from the University of Occupational and Environmental Health (UOEH) , Japan; an Overseas Research Grant for M.Y. from the Uehara Memorial Foundation, Japan ; a Grant-in-Aid for Scientific Research (B) (17H04027) KAKENHI for Y.U. from the MEXT, Japan; a Research Grant for Y.U. from The Salt Science Research Foundation (SSRF) (No. 2122), Japan; and United Kingdom Medical Research Council Grant MR/R010919/1 supporting B.C-C.

Publisher Copyright:
© 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arginine vasopressin
Hypothalamus
Circadian rhythm
Energy balance
HPA axis

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title = "Arginine vasopressin: Direct and indirect action on metabolism",

abstract = "From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.",

keywords = "Arginine vasopressin, Hypothalamus, Circadian rhythm, Energy balance, HPA axis",

author = "Mitsuhiro Yoshimura and Conway-Campbell, \{Becky L\} and Yoichi Ueta",

note = "Funding Information: We are grateful for Dr. Haruki Nishimura (UOEH) for his robust assessment of our manuscript. This article was supported by a Grant-in-Aid for Scientific Research (C) ( 21K06779 ) KAKENHI for M.Y. from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) , Japan; a Grant for Encouragement of Young Scientists for M.Y. from the University of Occupational and Environmental Health (UOEH) , Japan; an Overseas Research Grant for M.Y. from the Uehara Memorial Foundation, Japan ; a Grant-in-Aid for Scientific Research (B) (17H04027) KAKENHI for Y.U. from the MEXT, Japan; a Research Grant for Y.U. from The Salt Science Research Foundation (SSRF) (No. 2122), Japan; and United Kingdom Medical Research Council Grant MR/R010919/1 supporting B.C-C. Publisher Copyright: {\textcopyright} 2021",

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doi = "10.1016/j.peptides.2021.170555",

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AU - Yoshimura, Mitsuhiro

AU - Conway-Campbell, Becky L

AU - Ueta, Yoichi

N1 - Funding Information: We are grateful for Dr. Haruki Nishimura (UOEH) for his robust assessment of our manuscript. This article was supported by a Grant-in-Aid for Scientific Research (C) ( 21K06779 ) KAKENHI for M.Y. from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) , Japan; a Grant for Encouragement of Young Scientists for M.Y. from the University of Occupational and Environmental Health (UOEH) , Japan; an Overseas Research Grant for M.Y. from the Uehara Memorial Foundation, Japan ; a Grant-in-Aid for Scientific Research (B) (17H04027) KAKENHI for Y.U. from the MEXT, Japan; a Research Grant for Y.U. from The Salt Science Research Foundation (SSRF) (No. 2122), Japan; and United Kingdom Medical Research Council Grant MR/R010919/1 supporting B.C-C. Publisher Copyright: © 2021

PY - 2021/8

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N2 - From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.

AB - From its identification and isolation in 1954, arginine vasopressin (AVP) has attracted attention, not only for its peripheral functions such as vasoconstriction and reabsorption of water from kidney, but also for its central effects. As there is now considerable evidence that AVP plays a crucial role in feeding behavior and energy balance, it has become a promising therapeutic target for treating obesity or other obesity-related metabolic disorders. However, the underlying mechanisms for AVP regulation of these central processes still remain largely unknown. In this review, we will provide a brief overview of the current knowledge concerning how AVP controls energy balance and feeding behavior, focusing on physiological aspects including the relationship between AVP, circadian rhythmicity, and glucocorticoids.

KW - Arginine vasopressin

KW - Hypothalamus

KW - Circadian rhythm

KW - Energy balance

KW - HPA axis

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DO - 10.1016/j.peptides.2021.170555

M3 - Review article (Academic Journal)

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SN - 0196-9781

VL - 142

JO - Peptides

JF - Peptides

M1 - 170555

ER -

Arginine vasopressin: Direct and indirect action on metabolism

Abstract

Bibliographical note

UN SDGs

Keywords

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