Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI

A M Amadu; A Baritussio; A G Dastidar; E De Garate; J C L Rodrigues; G Biglino; S Lyen; I Diab; E Duncan; Ashley M Nisbet; Glyn Thomas; G D Angelini; C Bucciarelli-Ducci

doi:10.1016/j.crad.2018.12.002

Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI

A M Amadu, A Baritussio, A G Dastidar, E De Garate, J C L Rodrigues, G Biglino, S Lyen, I Diab, E Duncan, Ashley M Nisbet, Glyn Thomas, G D Angelini, C Bucciarelli-Ducci^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

AIM: To assess the role of cardiovascular magnetic resonance imaging (CMRI) in patients referred for suspected arrhythmogenic right ventricular cardiomyopathy (ARVC), its ability to identify ARVC mimics, and subsequent clinical impact.

MATERIALS AND METHODS: The CMRI registry of the year 2014 was analysed to identify all consecutive patients referred for suspected ARVC. A comprehensive CMRI protocol that included anatomy, bi-ventricular function modules, and late gadolinium enhancement (LGE) was performed in all patients.

RESULTS: Out of 2,481 CMRI performed, 124 patients (5%) were referred for suspected ARVC. A pathological substrate was identified at CMRI in 36 patients (29%): five patients (4%) had ischaemic heart disease (IHD) and 10 (8%) non-IHD; five patients (4%) met CMRI criteria for ARVC and 16 (13%) were ARVC mimics. right ventricular end-diastolic volume (RVEDV) and right ventricular stroke volume (RVSV) were significantly higher in patients with ARVC mimics (RVEDV p=0.007, RVSV p=0.012) and ARVC (RVEDV p=0.013, RVSV p=0.013), as compared to those with structurally normal hearts. CMRI was superior to echocardiography in the identification of ARVC mimics (13% versus 1%, p=0.01).

CONCLUSIONS: CMRI was able to identify 16 (13%) ARVC mimics, from congenital abnormalities to acquired heart disease. CMRI was superior in identifying ARVC mimics compared to echocardiography, and overall provided a change in diagnosis in 22% of patients.

Original language	English
Pages (from-to)	228-234
Number of pages	7
Journal	Clinical Radiology
Volume	74
Issue number	3
Early online date	23 Jan 2019
DOIs	https://doi.org/10.1016/j.crad.2018.12.002
Publication status	Published - Mar 2019

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Centre for Surgical Research

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Amadu, A. M., Baritussio, A., Dastidar, A. G., De Garate, E., Rodrigues, J. C. L., Biglino, G., Lyen, S., Diab, I., Duncan, E., Nisbet, A. M., Thomas, G., Angelini, G. D., & Bucciarelli-Ducci, C. (2019). Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI. Clinical Radiology, 74(3), 228-234. https://doi.org/10.1016/j.crad.2018.12.002

@article{2136374f80d64fc8a444229b5c10e1de,

title = "Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI",

abstract = "AIM: To assess the role of cardiovascular magnetic resonance imaging (CMRI) in patients referred for suspected arrhythmogenic right ventricular cardiomyopathy (ARVC), its ability to identify ARVC mimics, and subsequent clinical impact.MATERIALS AND METHODS: The CMRI registry of the year 2014 was analysed to identify all consecutive patients referred for suspected ARVC. A comprehensive CMRI protocol that included anatomy, bi-ventricular function modules, and late gadolinium enhancement (LGE) was performed in all patients.RESULTS: Out of 2,481 CMRI performed, 124 patients (5%) were referred for suspected ARVC. A pathological substrate was identified at CMRI in 36 patients (29%): five patients (4%) had ischaemic heart disease (IHD) and 10 (8%) non-IHD; five patients (4%) met CMRI criteria for ARVC and 16 (13%) were ARVC mimics. right ventricular end-diastolic volume (RVEDV) and right ventricular stroke volume (RVSV) were significantly higher in patients with ARVC mimics (RVEDV p=0.007, RVSV p=0.012) and ARVC (RVEDV p=0.013, RVSV p=0.013), as compared to those with structurally normal hearts. CMRI was superior to echocardiography in the identification of ARVC mimics (13% versus 1%, p=0.01).CONCLUSIONS: CMRI was able to identify 16 (13%) ARVC mimics, from congenital abnormalities to acquired heart disease. CMRI was superior in identifying ARVC mimics compared to echocardiography, and overall provided a change in diagnosis in 22% of patients.",

author = "Amadu, {A M} and A Baritussio and Dastidar, {A G} and {De Garate}, E and Rodrigues, {J C L} and G Biglino and S Lyen and I Diab and E Duncan and Nisbet, {Ashley M} and Glyn Thomas and Angelini, {G D} and C Bucciarelli-Ducci",

year = "2019",

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doi = "10.1016/j.crad.2018.12.002",

language = "English",

volume = "74",

pages = "228--234",

journal = "Clinical Radiology",

issn = "0009-9260",

publisher = "Blackwell Scientific Publications",

number = "3",

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Amadu, AM, Baritussio, A, Dastidar, AG, De Garate, E, Rodrigues, JCL, Biglino, G, Lyen, S, Diab, I, Duncan, E, Nisbet, AM, Thomas, G, Angelini, GD & Bucciarelli-Ducci, C 2019, 'Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI', Clinical Radiology, vol. 74, no. 3, pp. 228-234. https://doi.org/10.1016/j.crad.2018.12.002

TY - JOUR

T1 - Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics

T2 - the knot unravelled by cardiovascular MRI

AU - Amadu, A M

AU - Baritussio, A

AU - Dastidar, A G

AU - De Garate, E

AU - Rodrigues, J C L

AU - Biglino, G

AU - Lyen, S

AU - Diab, I

AU - Duncan, E

AU - Nisbet, Ashley M

AU - Thomas, Glyn

AU - Angelini, G D

AU - Bucciarelli-Ducci, C

PY - 2019/3

Y1 - 2019/3

N2 - AIM: To assess the role of cardiovascular magnetic resonance imaging (CMRI) in patients referred for suspected arrhythmogenic right ventricular cardiomyopathy (ARVC), its ability to identify ARVC mimics, and subsequent clinical impact.MATERIALS AND METHODS: The CMRI registry of the year 2014 was analysed to identify all consecutive patients referred for suspected ARVC. A comprehensive CMRI protocol that included anatomy, bi-ventricular function modules, and late gadolinium enhancement (LGE) was performed in all patients.RESULTS: Out of 2,481 CMRI performed, 124 patients (5%) were referred for suspected ARVC. A pathological substrate was identified at CMRI in 36 patients (29%): five patients (4%) had ischaemic heart disease (IHD) and 10 (8%) non-IHD; five patients (4%) met CMRI criteria for ARVC and 16 (13%) were ARVC mimics. right ventricular end-diastolic volume (RVEDV) and right ventricular stroke volume (RVSV) were significantly higher in patients with ARVC mimics (RVEDV p=0.007, RVSV p=0.012) and ARVC (RVEDV p=0.013, RVSV p=0.013), as compared to those with structurally normal hearts. CMRI was superior to echocardiography in the identification of ARVC mimics (13% versus 1%, p=0.01).CONCLUSIONS: CMRI was able to identify 16 (13%) ARVC mimics, from congenital abnormalities to acquired heart disease. CMRI was superior in identifying ARVC mimics compared to echocardiography, and overall provided a change in diagnosis in 22% of patients.

AB - AIM: To assess the role of cardiovascular magnetic resonance imaging (CMRI) in patients referred for suspected arrhythmogenic right ventricular cardiomyopathy (ARVC), its ability to identify ARVC mimics, and subsequent clinical impact.MATERIALS AND METHODS: The CMRI registry of the year 2014 was analysed to identify all consecutive patients referred for suspected ARVC. A comprehensive CMRI protocol that included anatomy, bi-ventricular function modules, and late gadolinium enhancement (LGE) was performed in all patients.RESULTS: Out of 2,481 CMRI performed, 124 patients (5%) were referred for suspected ARVC. A pathological substrate was identified at CMRI in 36 patients (29%): five patients (4%) had ischaemic heart disease (IHD) and 10 (8%) non-IHD; five patients (4%) met CMRI criteria for ARVC and 16 (13%) were ARVC mimics. right ventricular end-diastolic volume (RVEDV) and right ventricular stroke volume (RVSV) were significantly higher in patients with ARVC mimics (RVEDV p=0.007, RVSV p=0.012) and ARVC (RVEDV p=0.013, RVSV p=0.013), as compared to those with structurally normal hearts. CMRI was superior to echocardiography in the identification of ARVC mimics (13% versus 1%, p=0.01).CONCLUSIONS: CMRI was able to identify 16 (13%) ARVC mimics, from congenital abnormalities to acquired heart disease. CMRI was superior in identifying ARVC mimics compared to echocardiography, and overall provided a change in diagnosis in 22% of patients.

UR - http://www.scopus.com/inward/record.url?scp=85060314236&partnerID=8YFLogxK

U2 - 10.1016/j.crad.2018.12.002

DO - 10.1016/j.crad.2018.12.002

M3 - Article (Academic Journal)

C2 - 30685060

SN - 0009-9260

VL - 74

SP - 228

EP - 234

JO - Clinical Radiology

JF - Clinical Radiology

IS - 3

ER -

Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI

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Arrhythmogenic right ventricular cardiomyopathy (ARVC) mimics: the knot unravelled by cardiovascular MRI

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