Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

Oleg V Aslanidi, Michael A Colman, Jichao Zhao, Bruce H Smaill, Stephen H Gilbert, Jules C Hancox, Mark R Boyett, Henggui Zhang

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Abstract

Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in the pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model for the PVs and surrounding LA tissue. The model integrates canine PV and LA single cell electrophysiology with the respective 3D tissue geometry and fiber orientation reconstructed from micro-CT data. The model simulations demonstrate that a combination of tissue anisotropy and electrical heterogeneity between the PVs and LA causes a break-down of normal electrical excitation wave-fronts. This leads to the generation of a high-frequency re-entrant source near the PV sleeves. Evidence of such sources have been seen clinically in AF patients. In summary, our modeling results provide new insights into the arrhythmogenic mechanisms of re-entrant excitation waves underlying AF.
Original languageEnglish
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012)
Subtitle of host publicationProceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages203-206
Number of pages4
ISBN (Electronic)9781457717871
ISBN (Print)9781424441198
DOIs
Publication statusPublished - Jan 2013

Publication series

Name
ISSN (Print)1094-687X
ISSN (Electronic)1558-4615

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  • Cite this

    Aslanidi, O. V., Colman, M. A., Zhao, J., Smaill, B. H., Gilbert, S. H., Hancox, J. C., Boyett, M. R., & Zhang, H. (2013). Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA (pp. 203-206). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/EMBC.2012.6345906