Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

Oleg V Aslanidi; Michael A Colman; Jichao Zhao; Bruce H Smaill; Stephen H Gilbert; Jules C Hancox; Mark R Boyett; Henggui Zhang

doi:10.1109/EMBC.2012.6345906

Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

Oleg V Aslanidi
, Michael A Colman
, Jichao Zhao
, Bruce H Smaill
, Stephen H Gilbert
, Jules C Hancox
, Mark R Boyett
, Henggui Zhang

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

5 Citations (Scopus)

Abstract

Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in the pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model for the PVs and surrounding LA tissue. The model integrates canine PV and LA single cell electrophysiology with the respective 3D tissue geometry and fiber orientation reconstructed from micro-CT data. The model simulations demonstrate that a combination of tissue anisotropy and electrical heterogeneity between the PVs and LA causes a break-down of normal electrical excitation wave-fronts. This leads to the generation of a high-frequency re-entrant source near the PV sleeves. Evidence of such sources have been seen clinically in AF patients. In summary, our modeling results provide new insights into the arrhythmogenic mechanisms of re-entrant excitation waves underlying AF.

Original language	English
Title of host publication	2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012)
Subtitle of host publication	Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Pages	203-206
Number of pages	4
ISBN (Electronic)	9781457717871
ISBN (Print)	9781424441198
DOIs	https://doi.org/10.1109/EMBC.2012.6345906
Publication status	Published - Jan 2013

Publication series

Name
ISSN (Print)	1094-687X
ISSN (Electronic)	1558-4615

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Aslanidi, O. V., Colman, M. A., Zhao, J., Smaill, B. H., Gilbert, S. H., Hancox, J. C., Boyett, M. R., & Zhang, H. (2013). Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA (pp. 203-206). Institute of Electrical and Electronics Engineers (IEEE). https://doi.org/10.1109/EMBC.2012.6345906

Aslanidi, Oleg V ; Colman, Michael A ; Zhao, Jichao et al. / Arrhythmogenic substrate for atrial fibrillation : insights from an integrative computational model of pulmonary veins. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE), 2013. pp. 203-206

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title = "Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins",

abstract = "Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in the pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model for the PVs and surrounding LA tissue. The model integrates canine PV and LA single cell electrophysiology with the respective 3D tissue geometry and fiber orientation reconstructed from micro-CT data. The model simulations demonstrate that a combination of tissue anisotropy and electrical heterogeneity between the PVs and LA causes a break-down of normal electrical excitation wave-fronts. This leads to the generation of a high-frequency re-entrant source near the PV sleeves. Evidence of such sources have been seen clinically in AF patients. In summary, our modeling results provide new insights into the arrhythmogenic mechanisms of re-entrant excitation waves underlying AF.",

author = "Aslanidi, \{Oleg V\} and Colman, \{Michael A\} and Jichao Zhao and Smaill, \{Bruce H\} and Gilbert, \{Stephen H\} and Hancox, \{Jules C\} and Boyett, \{Mark R\} and Henggui Zhang",

year = "2013",

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doi = "10.1109/EMBC.2012.6345906",

language = "English",

isbn = "9781424441198",

publisher = "Institute of Electrical and Electronics Engineers (IEEE)",

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Aslanidi, OV, Colman, MA, Zhao, J, Smaill, BH, Gilbert, SH, Hancox, JC, Boyett, MR & Zhang, H 2013, Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins. in 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE), pp. 203-206. https://doi.org/10.1109/EMBC.2012.6345906

Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins. / Aslanidi, Oleg V; Colman, Michael A; Zhao, Jichao et al.
2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE), 2013. p. 203-206.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

TY - GEN

T1 - Arrhythmogenic substrate for atrial fibrillation

T2 - insights from an integrative computational model of pulmonary veins

AU - Aslanidi, Oleg V

AU - Colman, Michael A

AU - Zhao, Jichao

AU - Smaill, Bruce H

AU - Gilbert, Stephen H

AU - Hancox, Jules C

AU - Boyett, Mark R

AU - Zhang, Henggui

PY - 2013/1

Y1 - 2013/1

N2 - Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in the pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model for the PVs and surrounding LA tissue. The model integrates canine PV and LA single cell electrophysiology with the respective 3D tissue geometry and fiber orientation reconstructed from micro-CT data. The model simulations demonstrate that a combination of tissue anisotropy and electrical heterogeneity between the PVs and LA causes a break-down of normal electrical excitation wave-fronts. This leads to the generation of a high-frequency re-entrant source near the PV sleeves. Evidence of such sources have been seen clinically in AF patients. In summary, our modeling results provide new insights into the arrhythmogenic mechanisms of re-entrant excitation waves underlying AF.

AB - Mechanisms underlying the genesis of re-entrant substrate for atrial fibrillation (AF) in the pulmonary veins (PVs) and left atrium (LA) are not well understood. We develop a biophysically detailed computational model for the PVs and surrounding LA tissue. The model integrates canine PV and LA single cell electrophysiology with the respective 3D tissue geometry and fiber orientation reconstructed from micro-CT data. The model simulations demonstrate that a combination of tissue anisotropy and electrical heterogeneity between the PVs and LA causes a break-down of normal electrical excitation wave-fronts. This leads to the generation of a high-frequency re-entrant source near the PV sleeves. Evidence of such sources have been seen clinically in AF patients. In summary, our modeling results provide new insights into the arrhythmogenic mechanisms of re-entrant excitation waves underlying AF.

U2 - 10.1109/EMBC.2012.6345906

DO - 10.1109/EMBC.2012.6345906

M3 - Conference Contribution (Conference Proceeding)

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SN - 9781424441198

SP - 203

EP - 206

BT - 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012)

PB - Institute of Electrical and Electronics Engineers (IEEE)

ER -

Aslanidi OV, Colman MA, Zhao J, Smaill BH, Gilbert SH, Hancox JC et al. Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins. In 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE). 2013. p. 203-206 Epub 2012 Nov 12. doi: 10.1109/EMBC.2012.6345906

Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

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