Aryl azide photochemistry in defined protein environments.

Josie L Morris, Samuel Reddington, Damien Murphy, D. Dafydd Jones, James Platts, Eric Tippmann

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)


A genetically encoded precursor to an aryl nitrene, para-azidophenylalanine, was introduced site specifically into proteins to deduce if distinct environments were capable of caging a reactive organic intermediate. Following photolysis of mutant T4 lysozyme or green fluorescent proteins, EPR spectra showed, respectively, the presence of a triplet nitrene and an anilino radical.
Original languageEnglish
Pages (from-to)728-731
JournalOrganic Letters
Issue number4
Publication statusPublished - 25 Jan 2013


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