Assay of alterations in oxidative stress markers in pigs naturally infested with Sarcoptes scabiei var. suis

Umesh Dimri, S Bandyopadhyay, Shanker Kumar Singh, Rakesh Ranjan, R Mukherjee, M I Yatoo, P H Patra, U K De, A A Dar

Research output: Contribution to journalArticle (Academic Journal)

Abstract

The present study aimed to examine the status of antioxidant systems of the pigs naturally suffering from sarcoptic mange. Fifty nine pigs were divided into three groups, healthy control (group I, n=15), subclinical sarcoptic mange (group II, n=22) and clinical sarcoptic mange (group III, n=22). To assess the status of antioxidant systems; lipid peroxides (LPO), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), ascorbic acid, zinc and copper concentrations in the blood samples as well as LPO, SOD, CAT and glutathione-s-transferase (GST) activities in the skin were measured. The GSH, SOD, GPx, ascorbic acid, zinc, copper concentrations in blood were significantly lower in the pigs suffering from clinical and subclinical sarcoptic mange, when compared with the healthy control. However, LPO content of these infested pigs was significantly higher. The CAT, SOD and GST activities in the skin of the diseased pigs were significantly lower, whereas LPO was significantly higher as compared to the healthy control. From the present study, it may be concluded that sarcoptic mange bestows remarkable alterations in the oxidative stress markers and imposes compromisation of the antioxidant status of the infested pigs.

Original languageEnglish
Pages (from-to)295-9
Number of pages5
JournalVeterinary Parasitology
Volume205
Issue number1-2
DOIs
Publication statusPublished - 15 Sep 2014

Bibliographical note

Copyright © 2014 Elsevier B.V. All rights reserved.

Keywords

  • Animals
  • Antioxidants/metabolism
  • Ascorbic Acid/blood
  • Biomarkers/metabolism
  • Catalase/metabolism
  • Copper/blood
  • Glutathione/metabolism
  • Glutathione Peroxidase/metabolism
  • Oxidative Stress
  • Sarcoptes scabiei/physiology
  • Scabies/metabolism
  • Superoxide Dismutase/metabolism
  • Swine
  • Zinc/blood

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