Assembly and Positioning of the Oocyte Meiotic Spindle

Binyam Mogessie, Kathleen Scheffler, Melina Schuh

Research output: Contribution to journalReview article (Academic Journal)peer-review

37 Citations (Scopus)
419 Downloads (Pure)


Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte eliminates half of its chromosomes into a small cell termed a polar body. The egg is then released into the Fallopian tube, where it can be fertilized. Upon fertilization, the egg completes the second meiotic division, and the mitotic division of the embryo starts. This review highlights recent work that has shed light on the cytoskeletal structures that drive the meiotic divisions of the oocyte in mammals. In particular, we focus on how mammalian oocytes assemble a microtubule spindle in the absence of centrosomes, how they position the spindle in preparation for polar body extrusion, and how the spindle segregates the chromosomes. We primarily focus on mouse oocytes as a model system but also highlight recent insights from human oocytes.

Original languageEnglish
Pages (from-to)381-403
Number of pages23
JournalAnnual Review of Cell and Developmental Biology
Early online date20 Jul 2018
Publication statusPublished - 2018


  • meiosis
  • oocytes
  • centrosomes
  • spindle
  • chromosomes
  • kinetochores
  • asymmetric division


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