Assembly-line synthesis of organic molecules with tailored shapes

Matthew Burns*, Stephanie Essafi, Jessica R Bame, Stephanie P. Bull, Matthew P. Webster, Sebastien Balieu, James W. Dale, Craig P. Butts, Jeremy N. Harvey, Varinder K. Aggarwal

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

134 Citations (Scopus)

Abstract

Molecular 'assembly lines', in which organic molecules undergo iterative processes such as chain elongation and functional group manipulation, are found in many natural systems, including polyketide biosynthesis. Here we report the creation of such an assembly line using the iterative, reagent-controlled homologation of a boronic ester. This process relies on the reactivity of alpha-lithioethyl tri-isopropylbenzoate, which inserts into carbon-boron bonds with exceptionally high fidelity and stereocontrol; each chain-extension step generates a new boronic ester, which is immediately ready for further homologation. We used this method to generate organic molecules that contain ten contiguous, stereochemically defined methyl groups. Several stereoisomers were synthesized and shown to adopt different shapes-helical or linear-depending on the stereochemistry of the methyl groups. This work should facilitate the rational design of molecules with predictable shapes, which could have an impact in areas of molecular sciences in which bespoke molecules are required.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalNature
Volume513
Issue number7517
DOIs
Publication statusPublished - 10 Sep 2014

Structured keywords

  • BCS and TECS CDTs

Keywords

  • REAGENT-CONTROLLED HOMOLOGATION
  • BORONIC ESTERS
  • STEREOCONTROLLED SYNTHESIS
  • CONFORMATION DESIGN
  • NATURAL-PRODUCTS
  • ASYMMETRIC-SYNTHESIS
  • GRIGNARD-REAGENTS
  • CHIRAL CARBENOIDS
  • EFFICIENT
  • SEQUENCE

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Cite this

Burns, M., Essafi, S., Bame, J. R., Bull, S. P., Webster, M. P., Balieu, S., Dale, J. W., Butts, C. P., Harvey, J. N., & Aggarwal, V. K. (2014). Assembly-line synthesis of organic molecules with tailored shapes. Nature, 513(7517), 183-188. https://doi.org/10.1038/nature13711