Assessing cellular response to functionalized α-helical peptide hydrogels

Nazia Mehrban, Edgardo Abelardo, Alexandra Wasmuth, Kieran L Hudson, Leanne M Mullen, A R Thomson, Martin A Birchall, Derek N Woolfson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)
445 Downloads (Pure)

Abstract

α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

Original languageEnglish
Pages (from-to)1387-1391
Number of pages5
JournalAdvanced Healthcare Materials
Volume3
Issue number9
Early online date24 Mar 2014
DOIs
Publication statusPublished - Sep 2014

Bibliographical note

© 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Structured keywords

  • BCS and TECS CDTs

Keywords

  • 2D cell culture
  • tissue engineering
  • self-assembled fibers
  • peptide hydrogels
  • PC12 cells;

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