Assessing cellular response to functionalized α-helical peptide hydrogels

Nazia Mehrban; Edgardo Abelardo; Alexandra Wasmuth; Kieran L Hudson; Leanne M Mullen; A R Thomson; Martin A Birchall; Derek N Woolfson

doi:10.1002/adhm.201400065

Assessing cellular response to functionalized α-helical peptide hydrogels

Nazia Mehrban, Edgardo Abelardo, Alexandra Wasmuth, Kieran L Hudson, Leanne M Mullen, A R Thomson, Martin A Birchall, Derek N Woolfson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

21 Citations (Scopus)

445 Downloads (Pure)

Abstract

α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

Original language	English
Pages (from-to)	1387-1391
Number of pages	5
Journal	Advanced Healthcare Materials
Volume	3
Issue number	9
Early online date	24 Mar 2014
DOIs	https://doi.org/10.1002/adhm.201400065
Publication status	Published - Sep 2014

Bibliographical note

Structured keywords

BCS and TECS CDTs

Keywords

2D cell culture
tissue engineering
self-assembled fibers
peptide hydrogels
PC12 cells;

Access to Document

10.1002/adhm.201400065

Mehrban et al. - Advanced healthcare materials - 2014
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.19 MB

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2 Finished

3-month Core Capability for Chemistry Research
Crosby, J.
1/01/13 → 1/04/13
Project: Research
alpha-Helical peptide hydrogels as instructive scaffolds for 3D cell culture and tissue engineering
Woolfson, D. N.
1/11/10 → 1/05/14
Project: Research

Cite this

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title = "Assessing cellular response to functionalized α-helical peptide hydrogels",

abstract = "α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.",

keywords = "2D cell culture, tissue engineering, self-assembled fibers, peptide hydrogels, PC12 cells;",

author = "Nazia Mehrban and Edgardo Abelardo and Alexandra Wasmuth and Hudson, {Kieran L} and Mullen, {Leanne M} and Thomson, {A R} and Birchall, {Martin A} and Woolfson, {Derek N}",

note = "{\textcopyright} 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

month = sep,

doi = "10.1002/adhm.201400065",

language = "English",

volume = "3",

pages = "1387--1391",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "Wiley-VCH Verlag",

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Assessing cellular response to functionalized α-helical peptide hydrogels. / Mehrban, Nazia; Abelardo, Edgardo; Wasmuth, Alexandra; Hudson, Kieran L; Mullen, Leanne M; Thomson, A R; Birchall, Martin A; Woolfson, Derek N.

In: Advanced Healthcare Materials, Vol. 3, No. 9, 09.2014, p. 1387-1391.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

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AU - Mehrban, Nazia

AU - Abelardo, Edgardo

AU - Wasmuth, Alexandra

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AU - Mullen, Leanne M

AU - Thomson, A R

AU - Birchall, Martin A

AU - Woolfson, Derek N

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AB - α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

KW - 2D cell culture

KW - tissue engineering

KW - self-assembled fibers

KW - peptide hydrogels

KW - PC12 cells;

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DO - 10.1002/adhm.201400065

M3 - Article (Academic Journal)

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JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

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Assessing cellular response to functionalized α-helical peptide hydrogels

Abstract

Bibliographical note

Structured keywords

Keywords

Access to Document

3-month Core Capability for Chemistry Research

alpha-Helical peptide hydrogels as instructive scaffolds for 3D cell culture and tissue engineering

Cite this