Assessing cellular response to functionalized α-helical peptide hydrogels

Nazia Mehrban; Edgardo Abelardo; Alexandra Wasmuth; Kieran L Hudson; Leanne M Mullen; A R Thomson; Martin A Birchall; Derek N Woolfson

doi:10.1002/adhm.201400065

Assessing cellular response to functionalized α-helical peptide hydrogels

Nazia Mehrban
, Edgardo Abelardo
, Alexandra Wasmuth
, Kieran L Hudson
, Leanne M Mullen
, A R Thomson
, Martin A Birchall
, Derek N Woolfson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

39 Citations (Scopus)

553 Downloads (Pure)

Abstract

α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

Original language	English
Pages (from-to)	1387-1391
Number of pages	5
Journal	Advanced Healthcare Materials
Volume	3
Issue number	9
Early online date	24 Mar 2014
DOIs	https://doi.org/10.1002/adhm.201400065
Publication status	Published - Sept 2014

Bibliographical note

Research Groups and Themes

BCS and TECS CDTs
Bristol BioDesign Institute
Organic & Biological

Keywords

peptide hydrogels
synthetic biology
self-assembled fibers
tissue engineering
PC12 cells;
2D cell culture

Access to Document

10.1002/adhm.201400065

Mehrban et al. - Advanced healthcare materials - 2014
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Final published version, 1.19 MB

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@article{cf1be47863354e44912681b34f6f916e,

title = "Assessing cellular response to functionalized α-helical peptide hydrogels",

abstract = "α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.",

keywords = "peptide hydrogels, synthetic biology, self-assembled fibers, tissue engineering, PC12 cells;, 2D cell culture",

author = "Nazia Mehrban and Edgardo Abelardo and Alexandra Wasmuth and Hudson, \{Kieran L\} and Mullen, \{Leanne M\} and Thomson, \{A R\} and Birchall, \{Martin A\} and Woolfson, \{Derek N\}",

note = "{\textcopyright} 2014 The Authors. Published by WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2014",

month = sep,

doi = "10.1002/adhm.201400065",

language = "English",

volume = "3",

pages = "1387--1391",

journal = "Advanced Healthcare Materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Inc",

number = "9",

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TY - JOUR

T1 - Assessing cellular response to functionalized α-helical peptide hydrogels

AU - Mehrban, Nazia

AU - Abelardo, Edgardo

AU - Wasmuth, Alexandra

AU - Hudson, Kieran L

AU - Mullen, Leanne M

AU - Thomson, A R

AU - Birchall, Martin A

AU - Woolfson, Derek N

PY - 2014/9

Y1 - 2014/9

N2 - α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

AB - α-Helical peptide hydrogels are decorated with a cell-binding peptide motif (RGDS), which is shown to promote adhesion, proliferation, and differentiation of PC12 cells. Gel structure and integrity are maintained after functionalization. This opens possibilities for the bottom-up design and engineering of complex functional scaffolds for 2D and 3D cell cultures.

KW - peptide hydrogels

KW - synthetic biology

KW - self-assembled fibers

KW - tissue engineering

KW - PC12 cells;

KW - 2D cell culture

UR - https://www.scopus.com/pages/publications/84908045744

U2 - 10.1002/adhm.201400065

DO - 10.1002/adhm.201400065

M3 - Article (Academic Journal)

C2 - 24659615

SN - 2192-2640

VL - 3

SP - 1387

EP - 1391

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

IS - 9

ER -

Assessing cellular response to functionalized α-helical peptide hydrogels

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

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3-month Core Capability for Chemistry Research

alpha-Helical peptide hydrogels as instructive scaffolds for 3D cell culture and tissue engineering

Cite this

Assessing cellular response to functionalized α-helical peptide hydrogels

Abstract

Bibliographical note

Research Groups and Themes

Keywords

Access to Document

Handle.net

Other files and links

Fingerprint

Projects

3-month Core Capability for Chemistry Research

alpha-Helical peptide hydrogels as instructive scaffolds for 3D cell culture and tissue engineering

Cite this