Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

BK Gaiser, TF Fernandes, M Jepson, JR Lead, CR Tyler, V Stone

Research output: Contribution to journalArticle (Academic Journal)peer-review

89 Citations (Scopus)

Abstract

The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO2 particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO2 = micro CeO2. Such consistency suggests that further studies might allow extrapolation of results between different models and species.
Translated title of the contributionAssessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments
Original languageEnglish
Pages (from-to)1 - 4
Number of pages4
JournalEnvironmental Health
Volume8 (Sup 1):S2
DOIs
Publication statusPublished - Feb 2009

Bibliographical note

Other: Proceedings from Joint Environment and Human Health Programme: Annual Science Day Conference and Workshop Birmingham, UK. 24-25 February 2009

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