Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

Robin D Marlow; Adam Finn; John Henderson

doi:10.1136/thoraxjnl-2018-212203

Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

Robin D Marlow^*, Adam Finn, John Henderson

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

15 Citations (Scopus)

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Abstract

The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

Original language	English
Pages (from-to)	503-505
Number of pages	3
Journal	Thorax
Volume	74
Issue number	5
Early online date	4 Apr 2019
DOIs	https://doi.org/10.1136/thoraxjnl-2018-212203
Publication status	Published - 1 May 2019

Bibliographical note

Funding Information:
RM is funded by the NIHR as an Academic Clinical Lecturer and is a member of the NIHR Health Protection Research Unit in Evaluation of Interventions at University of Bristol.

Publisher Copyright:
© Author(s) (or their employer(s)) 2019.

Keywords

asthma epidemiology
clinical epidemiology
respiratory infection

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10.1136/thoraxjnl-2018-212203

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via BMJ Publishing at https://thorax.bmj.com/content/74/5/503 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 273 KBLicence: CC BY-NC

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title = "Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study",

abstract = "The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).",

keywords = "asthma epidemiology, clinical epidemiology, respiratory infection",

author = "Marlow, {Robin D} and Adam Finn and John Henderson",

note = "Funding Information: RM is funded by the NIHR as an Academic Clinical Lecturer and is a member of the NIHR Health Protection Research Unit in Evaluation of Interventions at University of Bristol. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2019.",

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T2 - A whole English birth cohort case-control study

AU - Marlow, Robin D

AU - Finn, Adam

AU - Henderson, John

N1 - Funding Information: RM is funded by the NIHR as an Academic Clinical Lecturer and is a member of the NIHR Health Protection Research Unit in Evaluation of Interventions at University of Bristol. Publisher Copyright: © Author(s) (or their employer(s)) 2019.

PY - 2019/5/1

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N2 - The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

AB - The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

KW - asthma epidemiology

KW - clinical epidemiology

KW - respiratory infection

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U2 - 10.1136/thoraxjnl-2018-212203

DO - 10.1136/thoraxjnl-2018-212203

M3 - Article (Academic Journal)

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AN - SCOPUS:85064003462

SN - 0040-6376

VL - 74

SP - 503

EP - 505

JO - Thorax

JF - Thorax

IS - 5

ER -

Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

Abstract

Bibliographical note

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Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

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Bibliographical note

Keywords

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