Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

Robin D Marlow*, Adam Finn, John Henderson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
260 Downloads (Pure)

Abstract

The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

Original languageEnglish
Pages (from-to)503-505
Number of pages3
JournalThorax
Volume74
Issue number5
Early online date4 Apr 2019
DOIs
Publication statusPublished - 1 May 2019

Bibliographical note

Funding Information:
RM is funded by the NIHR as an Academic Clinical Lecturer and is a member of the NIHR Health Protection Research Unit in Evaluation of Interventions at University of Bristol.

Publisher Copyright:
© Author(s) (or their employer(s)) 2019.

Keywords

  • asthma epidemiology
  • clinical epidemiology
  • respiratory infection

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