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Assessing the association between bronchiolitis in infancy and recurrent wheeze: A whole English birth cohort case-control study

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)503-505
Number of pages3
Issue number5
Early online date11 Apr 2019
DateAccepted/In press - 26 Nov 2018
DateE-pub ahead of print - 11 Apr 2019
DatePublished (current) - 1 May 2019


The precise association between bronchiolitis and predisposition to childhood wheeze is unclear. We assessed bronchiolitis aetiology and later wheeze phenotypes in the entire 2007 English birth cohort. All infants admitted to hospital in England during their first year of life with bronchiolitis or urinary tract infection (UTI) were followed using Hospital Episode Statistics to determine risk and characteristics of wheeze admission over the subsequent 8 years. In our cohort of 21 272 children compared with UTI, the risk of wheeze admission was higher with previous bronchiolitis (risk ratio (RR) 2.4), even higher in those with non-respiratory syncytial virus bronchiolitis (RR 3.1) and persisted into late-onset wheeze (RR 1.7).

    Research areas

  • asthma epidemiology, clinical epidemiology, respiratory infection

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via BMJ Publishing at . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 273 KB, PDF document

    Licence: CC BY-NC


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