Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study

Sarah L. Hardoon*, Peter H. Whincup, S. Goya Wannamethee, Lucy T. Lennon, Simon Capewell, Richard W. Morris

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Aims To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men.

Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978-1980, aged 40-59 years) and after 20 years (1998-2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP -7.6mmHg (95% confidence interval: -9.7 to -5.4); diastolic BP +3.3mmHg (+2.2 to +4.5); non-high-density lipoprotein (HDL)-cholesterol -0.4 mmol/l (-0.5 to -0.2); HDL-cholesterol +0.16 mmol/l (+0.13 to +0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by -12.3mmHg (-14.7 to -9.9) and -1.6mmHg (-3.7 to +0.5) among medication users and men not using medication, respectively (P

Conclusion Decreases in BP were largely confined to medication users and overall changes in non-HDL-cholesterol were modest, suggesting the need for greater efforts to reduce BP and cholesterol among the general population. HDL-cholesterol increased among all men, likely reflecting cohort-wide improvements in associated health behaviours. Eur J Cardiovasc Prev Rehabil 17:502-508 (C) 2010 The European Society of Cardiology

Original languageEnglish
Pages (from-to)502-508
Number of pages7
JournalEuropean Journal of Cardiovascular Prevention and Rehabilitation
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2010

Keywords

  • antihypertensive medication
  • blood pressure
  • cholesterol
  • epidemiology
  • lipid-regulating medication
  • time trends
  • HEART-DISEASE MORTALITY
  • BLOOD-PRESSURE
  • CARDIOVASCULAR-DISEASE
  • MONICA PROJECT
  • VASCULAR MORTALITY
  • RANDOMIZED-TRIALS
  • INDIVIDUAL DATA
  • CHOLESTEROL
  • HYPERTENSION
  • POPULATION

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