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Assessment of tubule occlusion properties of an experimental stannous fluoride toothpaste: a randomised clinical in situ study

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalJournal of Dentistry
Volume76
Early online date5 Jul 2018
DOIs
DateAccepted/In press - 4 Jul 2018
DateE-pub ahead of print - 5 Jul 2018
DatePublished (current) - Sep 2018

Abstract

fluoride toothpaste: a randomised clinical in situ study Objectives: To evaluate the ability of a modified in situ model to differentiate dentinal tubule occlusion properties of toothpaste formulations over 10 days of treatment. Methods: This was a single-centre, three-treatment period, crossover, randomised, single-blind study with healthy participants wearing two lower oral appliances, each retaining four dentine samples, for 10 treatment days during each period of the study. Samples were power-brushed ex vivo twice on each treatment day with a Test toothpaste containing 0.454% stannous fluoride, a Control fluoride toothpaste containing 0.76% sodium monofluorophosphate, or mineral water. Dentine samples were subjected to in situ acid challenge (orange juice) on Days 9 and 10. Scanning electron microscopy images obtained at baseline and after 1, 4, 8 and 10 days of treatment were graded for degree of surface coverage by four calibrated examiners; the primary study endpoint was Day 8. Results: After 4, but not 8, days’ treatment, the degree of tubule occlusion increased in the dentine samples treated with the Test or Control toothpastes compared with the water-treated samples (p<0.01 and p<0.05, respectively). Following the acid challenge (Day 10), there was a statistically significantly greater degree of occlusion in the Test toothpaste-treated dentine samples compared with those treated with water (p<0.01). No other comparisons were statistically significant. All study treatments were generally well tolerated. Conclusions: This modified in situ model was unable to demonstrate statistically significant between-treatment differences in dentinal tubule occlusion after 8 days. Conversely, there are recognised developments that could be made to better identify product differences. Clinicaltrials.gov: NCT02768194. Clinical significance: Dentine hypersensitivity can be managed through brushing with stannous fluoride toothpastes, which occlude patent dentine tubules. Clinical studies measure pain but in situ models are needed to demonstrate occlusion intra-orally. However, this study did not demonstrate superior occlusion with stannous toothpaste; further methodological development is required to investigate its mode of action.

    Research areas

  • crossover, Dentine Hypersensitivity, Dentineal tubule occlusion, in situ model, Stannous fluoride, toothpaste

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