Assessment of unstable atherosclerosis in mice

CL Jackson, MR Bennett, EA Biessen, JL Johnson, R Krams

Research output: Contribution to journalArticle (Academic Journal)peer-review

94 Citations (Scopus)

Abstract

There is an urgent need for representative animal models where prospective examination of the events leading up to plaque rupture and the rupture process itself can be performed. Recently, reports have begun to emerge that apolipoprotein E and low density lipoprotein receptor knockout mice may spontaneously develop unstable atherosclerosis, with plaques in certain parts of the arterial tree showing features suggestive of plaque rupture. Here we discuss the problems inherent in applying definitions of plaque rupture as seen in human arteries to mice; the anatomic locations in mice where unstable plaques do and do not occur; methods of inducing plaque instability in mice; and how to assess plaque stability in mice. These considerations lead us to a number of general recommendations.
Translated title of the contributionAssessment of unstable atherosclerosis in mice
Original languageEnglish
Pages (from-to)714 - 720
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume27 (4)
DOIs
Publication statusPublished - Apr 2007

Bibliographical note

Publisher: Lippincott, Williams & Wilkins

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