Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P. Sklar, S. G. Schwab, Nigel Melville Williams, M. Daly, S. Schaffner, W. Maier, M. Albus, M. Trixler, P. Eichhammer, B. Lerer, J. Hallmayer, N. Norton, H. Williams, Stanley Zammit, A. G. Cardno, S. Jones, G. McCarthy

Research output: Contribution to journalArticle (Academic Journal)peer-review

55 Citations (Scopus)

Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
Original languageUndefined/Unknown
Pages (from-to)126-128
Number of pages3
JournalNature Genetics
Volume28
Issue number2
Publication statusPublished - 1 Jun 2001

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