Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P. Sklar; S. G. Schwab; Nigel Melville Williams; M. Daly; S. Schaffner; W. Maier; M. Albus; M. Trixler; P. Eichhammer; B. Lerer; J. Hallmayer; N. Norton; H. Williams; Stanley Zammit; A. G. Cardno; S. Jones; G. McCarthy

Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P. Sklar, S. G. Schwab, Nigel Melville Williams, M. Daly, S. Schaffner, W. Maier, M. Albus, M. Trixler, P. Eichhammer, B. Lerer, J. Hallmayer, N. Norton, H. Williams, Stanley Zammit, A. G. Cardno, S. Jones, G. McCarthy

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Original language	Undefined/Unknown
Pages (from-to)	126-128
Number of pages	3
Journal	Nature Genetics
Volume	28
Issue number	2
Publication status	Published - 1 Jun 2001

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@article{631da959221c43d0a1998abfcb4989a7,

title = "Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls",

abstract = "A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.",

author = "P. Sklar and Schwab, \{S. G.\} and Williams, \{Nigel Melville\} and M. Daly and S. Schaffner and W. Maier and M. Albus and M. Trixler and P. Eichhammer and B. Lerer and J. Hallmayer and N. Norton and H. Williams and Stanley Zammit and Cardno, \{A. G.\} and S. Jones and G. McCarthy",

year = "2001",

month = jun,

day = "1",

language = "Undefined/Unknown",

volume = "28",

pages = "126--128",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

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TY - JOUR

T1 - Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

AU - Sklar, P.

AU - Schwab, S. G.

AU - Williams, Nigel Melville

AU - Daly, M.

AU - Schaffner, S.

AU - Maier, W.

AU - Albus, M.

AU - Trixler, M.

AU - Eichhammer, P.

AU - Lerer, B.

AU - Hallmayer, J.

AU - Norton, N.

AU - Williams, H.

AU - Zammit, Stanley

AU - Cardno, A. G.

AU - Jones, S.

AU - McCarthy, G.

PY - 2001/6/1

Y1 - 2001/6/1

N2 - A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

AB - A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

M3 - Article (Academic Journal)

SN - 1061-4036

VL - 28

SP - 126

EP - 128

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -