Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

Wiebke Schumacher; John Cockcroft; Nicholas J Timpson; Carmel M McEniery; John Gallacher; Ann Rumley; Gordon Lowe; George Davey Smith; Ian B Wilkinson; Yoav Ben-Shlomo

doi:10.1161/HYPERTENSIONAHA.108.117622

Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

Wiebke Schumacher, John Cockcroft, Nicholas J Timpson, Carmel M McEniery, John Gallacher, Ann Rumley, Gordon Lowe, George Davey Smith, Ian B Wilkinson, Yoav Ben-Shlomo

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P

Original language	English
Pages (from-to)	150-7
Number of pages	8
Journal	Hypertension
Volume	53
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.108.117622
Publication status	Published - 2009

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title = "Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity",

abstract = "Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P",

author = "Wiebke Schumacher and John Cockcroft and Timpson, {Nicholas J} and McEniery, {Carmel M} and John Gallacher and Ann Rumley and Gordon Lowe and Smith, {George Davey} and Wilkinson, {Ian B} and Yoav Ben-Shlomo",

year = "2009",

doi = "10.1161/HYPERTENSIONAHA.108.117622",

language = "English",

volume = "53",

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T1 - Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

AU - Schumacher, Wiebke

AU - Cockcroft, John

AU - Timpson, Nicholas J

AU - McEniery, Carmel M

AU - Gallacher, John

AU - Rumley, Ann

AU - Lowe, Gordon

AU - Smith, George Davey

AU - Wilkinson, Ian B

AU - Ben-Shlomo, Yoav

PY - 2009

Y1 - 2009

N2 - Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P

AB - Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P

U2 - 10.1161/HYPERTENSIONAHA.108.117622

DO - 10.1161/HYPERTENSIONAHA.108.117622

M3 - Article (Academic Journal)

C2 - 19075099

SN - 1524-4563

VL - 53

SP - 150

EP - 157

JO - Hypertension

JF - Hypertension

IS - 2

ER -

Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

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