Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity

Wiebke Schumacher, John Cockcroft, Nicholas J Timpson, Carmel M McEniery, John Gallacher, Ann Rumley, Gordon Lowe, George Davey Smith, Ian B Wilkinson, Yoav Ben-Shlomo

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

Abstract

Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P
Original languageEnglish
Pages (from-to)150-7
Number of pages8
JournalHypertension
Volume53
Issue number2
DOIs
Publication statusPublished - 2009

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