Association between CCL2 haplotypes and knee osteoarthritis

S L Hulin-Curtis; J L Bidwell; M J Perry

doi:10.1111/iji.12015

Association between CCL2 haplotypes and knee osteoarthritis

S L Hulin-Curtis, J L Bidwell, M J Perry

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Abstract

We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

Original language	English
Pages (from-to)	280-3
Number of pages	4
Journal	International Journal of Immunogenetics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/iji.12015
Publication status	Published - Aug 2013

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title = "Association between CCL2 haplotypes and knee osteoarthritis",

abstract = "We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.",

author = "Hulin-Curtis, {S L} and Bidwell, {J L} and Perry, {M J}",

note = "{\textcopyright} 2012 John Wiley & Sons Ltd.",

year = "2013",

month = aug,

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T1 - Association between CCL2 haplotypes and knee osteoarthritis

AU - Hulin-Curtis, S L

AU - Bidwell, J L

AU - Perry, M J

PY - 2013/8

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N2 - We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

AB - We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

U2 - 10.1111/iji.12015

DO - 10.1111/iji.12015

M3 - Article (Academic Journal)

C2 - 23211090

VL - 40

SP - 280

EP - 283

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

SN - 1744-3121

IS - 4

ER -

Association between CCL2 haplotypes and knee osteoarthritis

Abstract

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