Association between CCL2 haplotypes and knee osteoarthritis

S L Hulin-Curtis; J L Bidwell; M J Perry

doi:10.1111/iji.12015

Association between CCL2 haplotypes and knee osteoarthritis

S L Hulin-Curtis
, J L Bidwell
, M J Perry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Abstract

We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

Original language	English
Pages (from-to)	280-3
Number of pages	4
Journal	International Journal of Immunogenetics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/iji.12015
Publication status	Published - Aug 2013

Bibliographical note

Access to Document

10.1111/iji.12015

Handle.net

Persistent link

Cite this

@article{5f3d9bed7b794086a76826aba96b86cc,

title = "Association between CCL2 haplotypes and knee osteoarthritis",

abstract = "We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3\%). Genetic variation in the CCL2 gene may be associated with knee OA.",

author = "Hulin-Curtis, \{S L\} and Bidwell, \{J L\} and Perry, \{M J\}",

note = "{\textcopyright} 2012 John Wiley \& Sons Ltd.",

year = "2013",

month = aug,

doi = "10.1111/iji.12015",

language = "English",

volume = "40",

pages = "280--3",

journal = "International Journal of Immunogenetics",

issn = "1744-313X",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Association between CCL2 haplotypes and knee osteoarthritis

AU - Hulin-Curtis, S L

AU - Bidwell, J L

AU - Perry, M J

PY - 2013/8

Y1 - 2013/8

N2 - We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

AB - We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.

U2 - 10.1111/iji.12015

DO - 10.1111/iji.12015

M3 - Article (Academic Journal)

C2 - 23211090

SN - 1744-313X

VL - 40

SP - 280

EP - 283

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 4

ER -

Association between CCL2 haplotypes and knee osteoarthritis

Abstract

Bibliographical note

Access to Document

Handle.net

Fingerprint

Cite this