Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Sarah Schimansky*, Samantha Lang, Rhona Beynon, Christopher Penfold, Amy Davies, Andrea Waylen, Steve Thomas, Miranda Pring, Michael Pawlita, Tim Waterboer, Andy Ness

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)
165 Downloads (Pure)

Abstract

BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.

METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.

RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).

CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.

Original languageEnglish
Pages (from-to)1053-1062
Number of pages10
JournalHead and Neck
Volume41
Issue number4
Early online date14 Dec 2018
DOIs
Publication statusPublished - 1 Apr 2019

Structured keywords

  • ICEP

Keywords

  • comorbidity
  • ACE 27
  • survival
  • head and neck cancer
  • human papillomavirus

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