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Abstract
BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.
METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.
RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).
CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.
Original language | English |
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Pages (from-to) | 1053-1062 |
Number of pages | 10 |
Journal | Head and Neck |
Volume | 41 |
Issue number | 4 |
Early online date | 14 Dec 2018 |
DOIs | |
Publication status | Published - 1 Apr 2019 |
Research Groups and Themes
- ICEP
Keywords
- comorbidity
- ACE 27
- survival
- head and neck cancer
- human papillomavirus
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Profiles
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Dr Miranda Pring
- Bristol Dental School - Consultant Senior Lecturer in Oral Maxillofacial Pathology
Person: Academic