Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Sarah Schimansky; Samantha Lang; Rhona Beynon; Christopher Penfold; Amy Davies; Andrea Waylen; Steve Thomas; Miranda Pring; Michael Pawlita; Tim Waterboer; Andy Ness

doi:10.1002/hed.25543

Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Sarah Schimansky^*, Samantha Lang, Rhona Beynon, Christopher Penfold, Amy Davies, Andrea Waylen, Steve Thomas, Miranda Pring, Michael Pawlita, Tim Waterboer, Andy Ness

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

11 Citations (Scopus)

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Abstract

BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.

METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.

RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).

CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.

Original language	English
Pages (from-to)	1053-1062
Number of pages	10
Journal	Head and Neck
Volume	41
Issue number	4
Early online date	14 Dec 2018
DOIs	https://doi.org/10.1002/hed.25543
Publication status	Published - 1 Apr 2019

Structured keywords

ICEP

Keywords

comorbidity
ACE 27
survival
head and neck cancer
human papillomavirus

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10.1002/hed.25543

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1 Active

NIHR BRC Nutrition
Ness, A. R.
1/04/17 → 31/03/22
Project: Research, Parent

Professor Andy R Ness
- Andy.Ness@bristol.ac.uk
- Bristol Dental School - Professor of Epidemiology
- Bristol Population Health Science Institute
- Cancer
Person: Academic , Member
Dr Miranda Pring
- Miranda.Pring@bristol.ac.uk
- Bristol Dental School - Consultant Senior Lecturer in Oral Maxillofacial Pathology
Person: Academic
Professor Steve J Thomas
- Steve.Thomas@bristol.ac.uk
- Cancer
- Bristol Dental School - Professor in Oral and Maxillofacial Surgery
Person: Academic , Member

Cite this

@article{9e84bb3b47a14066ab5ad842977d8cb1,

title = "Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000",

abstract = "BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.",

keywords = "comorbidity, ACE 27, survival, head and neck cancer, human papillomavirus",

author = "Sarah Schimansky and Samantha Lang and Rhona Beynon and Christopher Penfold and Amy Davies and Andrea Waylen and Steve Thomas and Miranda Pring and Michael Pawlita and Tim Waterboer and Andy Ness",

year = "2019",

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doi = "10.1002/hed.25543",

language = "English",

volume = "41",

pages = "1053--1062",

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Association between comorbidity and survival in head and neck cancer : Results from Head and Neck 5000. / Schimansky, Sarah; Lang, Samantha; Beynon, Rhona ; Penfold, Christopher ; Davies, Amy ; Waylen, Andrea ; Thomas, Steve ; Pring, Miranda; Pawlita, Michael; Waterboer, Tim; Ness, Andy.

In: Head and Neck, Vol. 41, No. 4, 01.04.2019, p. 1053-1062.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Association between comorbidity and survival in head and neck cancer

T2 - Results from Head and Neck 5000

AU - Schimansky, Sarah

AU - Lang, Samantha

AU - Beynon, Rhona

AU - Penfold, Christopher

AU - Davies, Amy

AU - Waylen, Andrea

AU - Thomas, Steve

AU - Pring, Miranda

AU - Pawlita, Michael

AU - Waterboer, Tim

AU - Ness, Andy

PY - 2019/4/1

Y1 - 2019/4/1

N2 - BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.

AB - BACKGROUND: People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.METHODS: Survival analyses were performed using data from participants in a UK multicentre cohort study with cancers of the oral cavity (n = 668), oropharynx (n = 1074), and larynx (n = 530). Survival analyses were incrementally adjusted for age, sex, marital status, income, education, stage, alcohol, and smoking.RESULTS: After adjusting for demographic, clinical, and behavioral confounders, higher baseline comorbidity was associated with reduced overall survival (mild comorbidity HR = 1.4, 95% CI = 1.1, 1.7; moderate comorbidity HR = 1.7, 95% CI = 1.3, 2.2; severe comorbidity HR = 2.8, 95% CI = 1.9, 4.; P-trend<.001).CONCLUSIONS: Our findings suggest that comorbidity is an independent prognosticator for overall survival in head and neck cancer. Comorbid illnesses should be considered in the assessment and treatment planning of people with head and neck cancer.

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Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Abstract

Structured keywords

Keywords

Access to Document

NIHR BRC Nutrition

Professor Andy R Ness

Dr Miranda Pring

Professor Steve J Thomas

Cite this