Association between estimated pulse wave velocity and the risk of stroke in middle-aged men

Sae Young Jae*, Kevin Heffernan, Sudhir Kurl, Setor K Kunutsor, Jari A Laukkanen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)
120 Downloads (Pure)


Aims and methods. We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2,666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.

Results. During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the top versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).

Conclusion. These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.
Original languageEnglish
JournalInternational Journal of Stroke
Early online date12 Oct 2020
Publication statusE-pub ahead of print - 12 Oct 2020


  • vascular stiffness
  • pulse wave velocity
  • cerebrovascular
  • blood pressure


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