Association between estimated pulse wave velocity and the risk of stroke in middle-aged men

Sae Young Jae; Kevin Heffernan; Sudhir  Kurl; Setor K Kunutsor; Jari A Laukkanen

doi:10.1177/1747493020963762

Association between estimated pulse wave velocity and the risk of stroke in middle-aged men

Sae Young Jae^*, Kevin Heffernan, Sudhir Kurl, Setor K Kunutsor, Jari A Laukkanen

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Aims and methods. We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2,666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.

Results. During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the top versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).

Conclusion. These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.

Original language	English
Journal	International Journal of Stroke
Early online date	12 Oct 2020
DOIs	https://doi.org/10.1177/1747493020963762
Publication status	E-pub ahead of print - 12 Oct 2020

Keywords

vascular stiffness
pulse wave velocity
cerebrovascular
blood pressure

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@article{ee960150a7fd4f4f9cdb85251bece397,

title = "Association between estimated pulse wave velocity and the risk of stroke in middle-aged men",

abstract = "Aims and methods. We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2,666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.Results. During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the top versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).Conclusion. These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.",

keywords = "vascular stiffness, pulse wave velocity, cerebrovascular, blood pressure",

author = "Jae, {Sae Young} and Kevin Heffernan and Sudhir Kurl and Kunutsor, {Setor K} and Laukkanen, {Jari A}",

year = "2020",

month = oct,

day = "12",

doi = "10.1177/1747493020963762",

language = "English",

journal = "International Journal of Stroke",

issn = "1747-4949",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Association between estimated pulse wave velocity and the risk of stroke in middle-aged men

AU - Jae, Sae Young

AU - Heffernan, Kevin

AU - Kurl, Sudhir

AU - Kunutsor, Setor K

AU - Laukkanen, Jari A

PY - 2020/10/12

Y1 - 2020/10/12

N2 - Aims and methods. We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2,666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.Results. During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the top versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).Conclusion. These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.

AB - Aims and methods. We sought to examine the association between estimated pulse wave velocity (ePWV), a proxy of carotid-femoral pulse wave velocity, and stroke and its subtypes (ischemic and hemorrhagic) in a prospective cohort of 2,666 men (aged mean 53.1, range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study.Results. During a median 28-year follow-up, 471 incident stroke (397 ischemic and 94 hemorrhagic) events occurred. After adjusting for several established and emerging risk factors including age and pulse pressure, comparing the top versus bottom quartiles of ePWV, there was an increased risk of stroke (hazard ratio [HR] 2.37, 95% Confidence Interval [CI]: 1.57-3.58), ischemic stroke (HR 2.23, 95% CI, 1.42-3.50), and hemorrhagic stroke (HR 3.57, 95% CI, 1.45-8.76).Conclusion. These findings demonstrate that ePWV is independently associated with the risk of stroke in middle-aged men.

KW - vascular stiffness

KW - pulse wave velocity

KW - cerebrovascular

KW - blood pressure

U2 - 10.1177/1747493020963762

DO - 10.1177/1747493020963762

M3 - Article (Academic Journal)

C2 - 33045935

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4949

ER -