Association Between Estimated Pulse Wave Velocity and the Risk of Heart Failure in the Kuopio Ischemic Heart Disease Risk Factor Study: Estimated pulse wave velocity and the risk of heart failure

Sae Young Jae*, Kevin Heffernan, Sudhir Kurl, Setor K Kunutsor, Jari Laukkanen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

Abstract

Background: Increased aortic stiffness, assessed as carotid-femoral pulse wave velocity (cfPWV), is associated with incident heart failure risk.
Methods and Results: We examined the association between estimated pulse wave velocity (ePWV), derived from a regression equation using age and mean arterial pressure, and incident heart failure risk in a prospective cohort of 2,465 men (age range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study. During a median follow-up of 26 years, 431 heart failure events occurred. After adjusting for potential confounders (age, pulse pressure, body mass index, smoking, alcohol consumption, diabetes, history of cardiovascular disease (CVD), family history of CVD, use of medications [anti-hypertensive agents and lipid-lowering drugs], total cholesterol, high density lipoprotein-cholesterol, triglycerides, glucose, C-reactive protein, creatinine, socioeconomic status, and physical activity ), the highest levels of ePWV (> 10m/s) were significantly associated with an increased risk of heart failure (HR 2.04, 95% CI: 1.29-3.21), compared with the lowest level of ePWV (< 8.5m/s).
Conclusion: Increased ePWV is related to future heart failure risk, independent of several traditional CVD risk factors, in middle-aged men.
Original languageEnglish
JournalJournal of Cardiac Failure
Publication statusAccepted/In press - 17 Nov 2020

Keywords

  • carotid-femoral pulse wave velocity
  • heart failure

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