Abstract
Background: Increased aortic stiffness, assessed as carotid-femoral pulse wave velocity (cfPWV), is associated with incident heart failure risk.
Methods and Results: We examined the association between estimated pulse wave velocity (ePWV), derived from a regression equation using age and mean arterial pressure, and incident heart failure risk in a prospective cohort of 2,465 men (age range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study. During a median follow-up of 26 years, 431 heart failure events occurred. After adjusting for potential confounders (age, pulse pressure, body mass index, smoking, alcohol consumption, diabetes, history of cardiovascular disease (CVD), family history of CVD, use of medications [anti-hypertensive agents and lipid-lowering drugs], total cholesterol, high density lipoprotein-cholesterol, triglycerides, glucose, C-reactive protein, creatinine, socioeconomic status, and physical activity ), the highest levels of ePWV (> 10m/s) were significantly associated with an increased risk of heart failure (HR 2.04, 95% CI: 1.29-3.21), compared with the lowest level of ePWV (< 8.5m/s).
Conclusion: Increased ePWV is related to future heart failure risk, independent of several traditional CVD risk factors, in middle-aged men.
Methods and Results: We examined the association between estimated pulse wave velocity (ePWV), derived from a regression equation using age and mean arterial pressure, and incident heart failure risk in a prospective cohort of 2,465 men (age range 42-61 years) enrolled in the Kuopio Ischemic Heart Disease cohort study. During a median follow-up of 26 years, 431 heart failure events occurred. After adjusting for potential confounders (age, pulse pressure, body mass index, smoking, alcohol consumption, diabetes, history of cardiovascular disease (CVD), family history of CVD, use of medications [anti-hypertensive agents and lipid-lowering drugs], total cholesterol, high density lipoprotein-cholesterol, triglycerides, glucose, C-reactive protein, creatinine, socioeconomic status, and physical activity ), the highest levels of ePWV (> 10m/s) were significantly associated with an increased risk of heart failure (HR 2.04, 95% CI: 1.29-3.21), compared with the lowest level of ePWV (< 8.5m/s).
Conclusion: Increased ePWV is related to future heart failure risk, independent of several traditional CVD risk factors, in middle-aged men.
| Original language | English |
|---|---|
| Pages (from-to) | 494-496 |
| Number of pages | 3 |
| Journal | Journal of Cardiac Failure |
| Volume | 27 |
| Issue number | 4 |
| Early online date | 24 Nov 2020 |
| DOIs | |
| Publication status | Published - 1 Apr 2021 |
Keywords
- carotid-femoral pulse wave velocity
- heart failure
Access to Document
- Full-text PDF (author’s accepted manuscript)
This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at 10.1016/j.cardfail.2020.11.012. Please refer to any applicable terms of use of the publisher.