Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Marcus R Munafò, Maria N Timofeeva, Richard W Morris, David Prieto-Merino, Naveed Sattar, Paul Brennan, Elaine C Johnstone, Caroline Relton, Paul C D Johnson, Donna Walther, Peter H Whincup, Juan P Casas, George R Uhl, Paolo Vineis, Sandosh Padmanabhan, Barbara J Jefferis, Antoinette Amuzu, Elio Riboli, Mark N Upton, Paul AveyardShah Ebrahim, Aroon D Hingorani, Graham Watt, Tom M Palmer, Nicholas J Timpson, George Davey Smith, EPIC Study Group

Research output: Contribution to journalArticle (Academic Journal)peer-review

129 Citations (Scopus)

Abstract

Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.
Translated title of the contributionAssociation between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure
Original languageEnglish
Pages (from-to)740 - 748
Number of pages9
JournalJournal of the National Cancer Institute
Volume104
Issue number10
Early online date25 Apr 2012
DOIs
Publication statusPublished - May 2012

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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