Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Marcus R Munafò; Maria N Timofeeva; Richard W Morris; David Prieto-Merino; Naveed Sattar; Paul Brennan; Elaine C Johnstone; Caroline Relton; Paul C D Johnson; Donna Walther; Peter H Whincup; Juan P Casas; George R Uhl; Paolo Vineis; Sandosh Padmanabhan; Barbara J Jefferis; Antoinette Amuzu; Elio Riboli; Mark N Upton; Paul Aveyard; Shah Ebrahim; Aroon D Hingorani; Graham Watt; Tom M Palmer; Nicholas J Timpson; George Davey Smith; EPIC Study Group

doi:10.1093/jnci/djs191

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Marcus R Munafò, Maria N Timofeeva, Richard W Morris, David Prieto-Merino, Naveed Sattar, Paul Brennan, Elaine C Johnstone, Caroline Relton, Paul C D Johnson, Donna Walther, Peter H Whincup, Juan P Casas, George R Uhl, Paolo Vineis, Sandosh Padmanabhan, Barbara J Jefferis, Antoinette Amuzu, Elio Riboli, Mark N Upton, Paul AveyardShah Ebrahim, Aroon D Hingorani, Graham Watt, Tom M Palmer, Nicholas J Timpson, George Davey Smith, EPIC Study Group

Research output: Contribution to journal › Article (Academic Journal) › peer-review

149 Citations (Scopus)

Abstract

Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.

Translated title of the contribution	Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure
Original language	English
Pages (from-to)	740 - 748
Number of pages	9
Journal	Journal of the National Cancer Institute
Volume	104
Issue number	10
Early online date	25 Apr 2012
DOIs	https://doi.org/10.1093/jnci/djs191
Publication status	Published - May 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Groups and Themes

Brain and Behaviour
Tobacco and Alcohol
TARG

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Munafò, M. R., Timofeeva, M. N., Morris, R. W., Prieto-Merino, D., Sattar, N., Brennan, P., Johnstone, E. C., Relton, C., Johnson, P. C. D., Walther, D., Whincup, P. H., Casas, J. P., Uhl, G. R., Vineis, P., Padmanabhan, S., Jefferis, B. J., Amuzu, A., Riboli, E., Upton, M. N., ... EPIC Study Group (2012). Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. Journal of the National Cancer Institute, 104(10), 740 - 748. https://doi.org/10.1093/jnci/djs191

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title = "Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure",

abstract = "Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.",

author = "Munaf{\`o}, \{Marcus R\} and Timofeeva, \{Maria N\} and Morris, \{Richard W\} and David Prieto-Merino and Naveed Sattar and Paul Brennan and Johnstone, \{Elaine C\} and Caroline Relton and Johnson, \{Paul C D\} and Donna Walther and Whincup, \{Peter H\} and Casas, \{Juan P\} and Uhl, \{George R\} and Paolo Vineis and Sandosh Padmanabhan and Jefferis, \{Barbara J\} and Antoinette Amuzu and Elio Riboli and Upton, \{Mark N\} and Paul Aveyard and Shah Ebrahim and Hingorani, \{Aroon D\} and Graham Watt and Palmer, \{Tom M\} and Timpson, \{Nicholas J\} and \{Davey Smith\}, George and \{EPIC Study Group\}",

year = "2012",

month = may,

doi = "10.1093/jnci/djs191",

language = "English",

volume = "104",

pages = "740 -- 748",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "10",

}

Munafò, MR, Timofeeva, MN, Morris, RW, Prieto-Merino, D, Sattar, N, Brennan, P, Johnstone, EC, Relton, C, Johnson, PCD, Walther, D, Whincup, PH, Casas, JP, Uhl, GR, Vineis, P, Padmanabhan, S, Jefferis, BJ, Amuzu, A, Riboli, E, Upton, MN, Aveyard, P, Ebrahim, S, Hingorani, AD, Watt, G, Palmer, TM , Timpson, NJ , Davey Smith, G & EPIC Study Group 2012, 'Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure', Journal of the National Cancer Institute, vol. 104, no. 10, pp. 740 - 748. https://doi.org/10.1093/jnci/djs191

TY - JOUR

T1 - Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

AU - Munafò, Marcus R

AU - Timofeeva, Maria N

AU - Morris, Richard W

AU - Prieto-Merino, David

AU - Sattar, Naveed

AU - Brennan, Paul

AU - Johnstone, Elaine C

AU - Relton, Caroline

AU - Johnson, Paul C D

AU - Walther, Donna

AU - Whincup, Peter H

AU - Casas, Juan P

AU - Uhl, George R

AU - Vineis, Paolo

AU - Padmanabhan, Sandosh

AU - Jefferis, Barbara J

AU - Amuzu, Antoinette

AU - Riboli, Elio

AU - Upton, Mark N

AU - Aveyard, Paul

AU - Ebrahim, Shah

AU - Hingorani, Aroon D

AU - Watt, Graham

AU - Palmer, Tom M

AU - Timpson, Nicholas J

AU - Davey Smith, George

AU - EPIC Study Group

PY - 2012/5

Y1 - 2012/5

N2 - Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.

AB - Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.

UR - https://www.scopus.com/pages/publications/84861325364

U2 - 10.1093/jnci/djs191

DO - 10.1093/jnci/djs191

M3 - Article (Academic Journal)

C2 - 22534784

SN - 0027-8874

VL - 104

SP - 740

EP - 748

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 10

ER -

Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Abstract

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CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

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Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Abstract

UN SDGs

Research Groups and Themes

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CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

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