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Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)740 - 748
Number of pages9
JournalJournal of the National Cancer Institute
Volume104
Issue number10
Early online date25 Apr 2012
DOIs
DateE-pub ahead of print - 25 Apr 2012
DatePublished (current) - May 2012

Abstract

Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking-related health outcomes. Previous studies have typically relied on self-reported smoking behavior, which may not fully capture interindividual variation in tobacco exposure.

    Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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