Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort

Miharu Nakanishi; Kaori Endo; Syudo  Yamasaki; Daniel Stanyon; Sarah A Sullivan; Satoshi Yamaguchi; Shuntaro Ando; Mariko Hiraiwa-Hasegawa; Kiyoto Kasai; Atsushi Nishida; Mitsuhiro Miyashita

doi:10.1016/j.jad.2023.08.055

Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  

Miharu Nakanishi^*, Kaori Endo, Syudo Yamasaki, Daniel Stanyon, Sarah A Sullivan, Satoshi Yamaguchi, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida, Mitsuhiro Miyashita

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Abstract

Background
Midlife suicide among women has attracted increasing research attention. This study aimed to investigate the longitudinal association between menopause and suicidal ideation among middle-aged women.
Methods
Our data were derived from the Tokyo Teen Cohort, a population-based survey of early adolescents (N = 3171) and their primary caregivers (typically, mothers) in Japan. A total of 2944 mothers (baseline mean age = 44.0 years) were included in the analysis. The baseline assessment in this study was performed at second-wave survey from July 2014 to January 2017. A follow-up assessment was conducted at fourth-wave survey from February 2019 to September 2021. Suicidal ideation at baseline and follow-up was assessed using the Suicidal
Ideation subscale of the 28-item General Health Questionnaire. Menopausal stage was classified based on self-report at fourth-wave survey.
Results
Participants who started the perimenopausal stage after baseline were significantly more likely to have suicidal ideation at follow-up than those who did not have experienced menopausal transition yet. Participants with greater social support were less likely to report suicidal ideation at follow-up, even after adjusting for baseline suicidal ideation.
Limitations
This study was based on self-report regarding menopausal stage and only included mothers of adolescents from Japan. An exact length of time from the onset to the presence of suicidal ideation was unavailable.
Conclusions
Women who have experienced the onset of menopausal transition presented an increased risk of suicidal ideation. Psychosocial interventions to increase social support may be beneficial in preventing mental health inequalities during menopausal transitions.

Original language	English
Pages (from-to)	529-534
Number of pages	6
Journal	Journal of Affective Disorders
Volume	340
Early online date	16 Aug 2023
DOIs	https://doi.org/10.1016/j.jad.2023.08.055
Publication status	E-pub ahead of print - 16 Aug 2023

Bibliographical note

Funding Information:
This work was supported by a Grant-in-Aid for Transformative Research Areas (A) from the Ministry of Education, Culture, Sports, Science and Technology of Japan [grant numbers JP21H05171 , JP21H05173 , JP21H05174 ]; Tokyo Metropolitan Government [project number 4福保高在第1405号]; and Tokyo Metropolitan Institute of Medical Science [project number 2508].

Publisher Copyright:
© 2023 The Authors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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Nakanishi, M., Endo, K., Yamasaki, S., Stanyon, D., Sullivan, S. A., Yamaguchi, S., Ando, S., Hiraiwa-Hasegawa, M., Kasai, K., Nishida, A., & Miyashita, M. (2023). Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  . Journal of Affective Disorders, 340, 529-534. Advance online publication. https://doi.org/10.1016/j.jad.2023.08.055

@article{37b7711c5a3944fab46e2842f44184c7,

title = "Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  ",

abstract = "Background Midlife suicide among women has attracted increasing research attention. This study aimed to investigate the longitudinal association between menopause and suicidal ideation among middle-aged women. Methods Our data were derived from the Tokyo Teen Cohort, a population-based survey of early adolescents (N = 3171) and their primary caregivers (typically, mothers) in Japan. A total of 2944 mothers (baseline mean age = 44.0 years) were included in the analysis. The baseline assessment in this study was performed at second-wave survey from July 2014 to January 2017. A follow-up assessment was conducted at fourth-wave survey from February 2019 to September 2021. Suicidal ideation at baseline and follow-up was assessed using the Suicidal Ideation subscale of the 28-item General Health Questionnaire. Menopausal stage was classified based on self-report at fourth-wave survey. Results Participants who started the perimenopausal stage after baseline were significantly more likely to have suicidal ideation at follow-up than those who did not have experienced menopausal transition yet. Participants with greater social support were less likely to report suicidal ideation at follow-up, even after adjusting for baseline suicidal ideation. Limitations This study was based on self-report regarding menopausal stage and only included mothers of adolescents from Japan. An exact length of time from the onset to the presence of suicidal ideation was unavailable. Conclusions Women who have experienced the onset of menopausal transition presented an increased risk of suicidal ideation. Psychosocial interventions to increase social support may be beneficial in preventing mental health inequalities during menopausal transitions.",

author = "Miharu Nakanishi and Kaori Endo and Syudo Yamasaki and Daniel Stanyon and Sullivan, \{Sarah A\} and Satoshi Yamaguchi and Shuntaro Ando and Mariko Hiraiwa-Hasegawa and Kiyoto Kasai and Atsushi Nishida and Mitsuhiro Miyashita",

note = "Funding Information: This work was supported by a Grant-in-Aid for Transformative Research Areas (A) from the Ministry of Education, Culture, Sports, Science and Technology of Japan [grant numbers JP21H05171 , JP21H05173 , JP21H05174 ]; Tokyo Metropolitan Government [project number 4福保高在第1405号]; and Tokyo Metropolitan Institute of Medical Science [project number 2508]. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = aug,

day = "16",

doi = "10.1016/j.jad.2023.08.055",

language = "English",

volume = "340",

pages = "529--534",

journal = "Journal of Affective Disorders",

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publisher = "Elsevier B.V.",

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Nakanishi, M, Endo, K, Yamasaki, S, Stanyon, D, Sullivan, SA, Yamaguchi, S, Ando, S, Hiraiwa-Hasegawa, M, Kasai, K, Nishida, A & Miyashita, M 2023, 'Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  ', Journal of Affective Disorders, vol. 340, pp. 529-534. https://doi.org/10.1016/j.jad.2023.08.055

TY - JOUR

T1 - Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  

AU - Nakanishi, Miharu

AU - Endo, Kaori

AU - Yamasaki, Syudo

AU - Stanyon, Daniel

AU - Sullivan, Sarah A

AU - Yamaguchi, Satoshi

AU - Ando, Shuntaro

AU - Hiraiwa-Hasegawa, Mariko

AU - Kasai, Kiyoto

AU - Nishida, Atsushi

AU - Miyashita, Mitsuhiro

N1 - Funding Information: This work was supported by a Grant-in-Aid for Transformative Research Areas (A) from the Ministry of Education, Culture, Sports, Science and Technology of Japan [grant numbers JP21H05171 , JP21H05173 , JP21H05174 ]; Tokyo Metropolitan Government [project number 4福保高在第1405号]; and Tokyo Metropolitan Institute of Medical Science [project number 2508]. Publisher Copyright: © 2023 The Authors

PY - 2023/8/16

Y1 - 2023/8/16

N2 - Background Midlife suicide among women has attracted increasing research attention. This study aimed to investigate the longitudinal association between menopause and suicidal ideation among middle-aged women. Methods Our data were derived from the Tokyo Teen Cohort, a population-based survey of early adolescents (N = 3171) and their primary caregivers (typically, mothers) in Japan. A total of 2944 mothers (baseline mean age = 44.0 years) were included in the analysis. The baseline assessment in this study was performed at second-wave survey from July 2014 to January 2017. A follow-up assessment was conducted at fourth-wave survey from February 2019 to September 2021. Suicidal ideation at baseline and follow-up was assessed using the Suicidal Ideation subscale of the 28-item General Health Questionnaire. Menopausal stage was classified based on self-report at fourth-wave survey. Results Participants who started the perimenopausal stage after baseline were significantly more likely to have suicidal ideation at follow-up than those who did not have experienced menopausal transition yet. Participants with greater social support were less likely to report suicidal ideation at follow-up, even after adjusting for baseline suicidal ideation. Limitations This study was based on self-report regarding menopausal stage and only included mothers of adolescents from Japan. An exact length of time from the onset to the presence of suicidal ideation was unavailable. Conclusions Women who have experienced the onset of menopausal transition presented an increased risk of suicidal ideation. Psychosocial interventions to increase social support may be beneficial in preventing mental health inequalities during menopausal transitions.

AB - Background Midlife suicide among women has attracted increasing research attention. This study aimed to investigate the longitudinal association between menopause and suicidal ideation among middle-aged women. Methods Our data were derived from the Tokyo Teen Cohort, a population-based survey of early adolescents (N = 3171) and their primary caregivers (typically, mothers) in Japan. A total of 2944 mothers (baseline mean age = 44.0 years) were included in the analysis. The baseline assessment in this study was performed at second-wave survey from July 2014 to January 2017. A follow-up assessment was conducted at fourth-wave survey from February 2019 to September 2021. Suicidal ideation at baseline and follow-up was assessed using the Suicidal Ideation subscale of the 28-item General Health Questionnaire. Menopausal stage was classified based on self-report at fourth-wave survey. Results Participants who started the perimenopausal stage after baseline were significantly more likely to have suicidal ideation at follow-up than those who did not have experienced menopausal transition yet. Participants with greater social support were less likely to report suicidal ideation at follow-up, even after adjusting for baseline suicidal ideation. Limitations This study was based on self-report regarding menopausal stage and only included mothers of adolescents from Japan. An exact length of time from the onset to the presence of suicidal ideation was unavailable. Conclusions Women who have experienced the onset of menopausal transition presented an increased risk of suicidal ideation. Psychosocial interventions to increase social support may be beneficial in preventing mental health inequalities during menopausal transitions.

U2 - 10.1016/j.jad.2023.08.055

DO - 10.1016/j.jad.2023.08.055

M3 - Article (Academic Journal)

C2 - 37573891

SN - 0165-0327

VL - 340

SP - 529

EP - 534

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort

Abstract

Bibliographical note

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Association between menopause and suicidal ideation in mothers of adolescents: a longitudinal study using data from a population-based cohort  