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Abstract
Aim: The aim of this work is to test if three single nucleotide polymorphisms (SNPs) implicated in glutamate homeostasis or signalling and cellular survival are associated with birth condition.
Methods: This study is drawn from the Avon Longitudinal Study of Parents and Children. 7611 term infants were genotyped and patient outcome data retrieved from routine medical records. Exposure measures were the presence of one or more minor alleles in one of 3 SNPs (rs2284411, rs2498804, rs1835740). The primary outcome was the need for resuscitation at birth.
Results: For SNP rs1835740, infants homozygous for the minor allele compared to wild-type were more likely to need resuscitation (9.2% vs. 7.0%, p=0.041) while the odds ratio for resuscitation was associated with each increasing minor allele (OR 1.17 (1.01 to 1.35)). Population attributable risk fraction was 6.5%. There was no evidence that the other two SNPs investigated were associated with birth condition.
Conclusions: We have tested three candidate SNPs to measure any association with birth condition. The study revealed that the rs1835740 was associated with the need for resuscitation and Apgar scores, with a substantial population impact. This article is protected by copyright. All rights reserved.
Methods: This study is drawn from the Avon Longitudinal Study of Parents and Children. 7611 term infants were genotyped and patient outcome data retrieved from routine medical records. Exposure measures were the presence of one or more minor alleles in one of 3 SNPs (rs2284411, rs2498804, rs1835740). The primary outcome was the need for resuscitation at birth.
Results: For SNP rs1835740, infants homozygous for the minor allele compared to wild-type were more likely to need resuscitation (9.2% vs. 7.0%, p=0.041) while the odds ratio for resuscitation was associated with each increasing minor allele (OR 1.17 (1.01 to 1.35)). Population attributable risk fraction was 6.5%. There was no evidence that the other two SNPs investigated were associated with birth condition.
Conclusions: We have tested three candidate SNPs to measure any association with birth condition. The study revealed that the rs1835740 was associated with the need for resuscitation and Apgar scores, with a substantial population impact. This article is protected by copyright. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | e307-e312 |
| Number of pages | 6 |
| Journal | Acta Paediatrica |
| Volume | 105 |
| Issue number | 7 |
| Early online date | 5 Apr 2016 |
| DOIs | |
| Publication status | Published - Jul 2016 |
Bibliographical note
04/04/16Keywords
- Asphyxia Neonatorum
- Brain
- Cohort Studies
- Hypoxia-Ischemia
- Glutamate
- Polymorphism
Fingerprint
Dive into the research topics of 'Association between neonatal resuscitation and a single nucleotide polymorphism rs1835740'. Together they form a unique fingerprint.Projects
- 2 Finished
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Development of biotin-tagged affinity ligands and fluorophore-conjugated probes for the study of native kainate receptors
Molnar, E. (Principal Investigator)
1/03/13 → 1/03/16
Project: Research
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THE ROLE OF METABOTROPIC GLUTAMATE AND GABA-B RECEPTORS IN OLIGODENDROCYTE DEVELOPMENT, SURVIVAL AND VULNERABILITY IN THE IMMATURE BRAIN
Molnar, E. (Principal Investigator)
16/06/08 → 16/06/11
Project: Research
Profiles
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Professor Karen Luyt
- Bristol Medical School (THS) - Professor in Neonatal Medicine
- Bristol Poverty Institute
- Bristol Population Health Science Institute
- Bristol Neuroscience
Person: Academic , Member