Background: Evidence suggests that baseline quality of life (QOL) scores are independently prognostic for survival in patients with cancer, but the role of QOL data in predicting short-term outcome after surgery is uncertain. This study assessed the association between QOL scores and short-term outcomes after surgery for oesophageal and gastric cancer. Methods: Consecutive patients selected for oesophagectomy or total gastrectomy between November 2000 and May 2003 completed the European Organization for Research and Treatment of Cancer's quality of life questionnaire, QLQ-C30. Multivariable regression models, adjusting for known clinical risk factors, were used to investigate relationships between QOL scores, major morbidity, hospital stay and survival status at 6 months. Results: Of 130 patients, 121 completed the questionnaire (response rate 93Â·1 per cent). There were 29 major complications (24Â·0 per cent) and 22 patients (18Â·2 per cent) died within 6 months of operation. QOL scores were not associated with major morbidity but were significantly related to survival status at 6 months after adjusting for known clinical risk factors. A worse fatigue score of 10 points (scale 0-100) corresponded to an increase in the odds of death within 6 months of surgery of 37Â·4 (95 per cent confidence interval (c.i.) 12Â·4 to 67Â·8) per cent (P = 0Â·002). Pretreatment social function scores were moderately associated with hospital stay (P = 0Â·021); a reduction in social function by 10 points corresponded to an increase in hospital stay of 0Â·93 (95 per cent c.i. 0Â·12 to 1Â·74) days. Conclusion: QOL scores supplement standard staging procedures for oesophageal and gastric cancer by providing prognostic information, but they do not contribute to perioperative risk assessment. Copyright Â© 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
|Translated title of the contribution||Association between quality of life scores and short-term outcome after surgery for cancer of the oesophagus or gastric cardia|
|Pages (from-to)||1502 - 1507|
|Number of pages||6|
|Journal||British Journal of Surgery|
|Publication status||Published - Oct 2005|