Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers

MR Munafo; EC Johnstone; KI Welsh; RT Walton

doi:10.1038/sj.tpj.6500294

Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers

MR Munafo, EC Johnstone, KI Welsh, RT Walton

Research output: Contribution to journal › Article (Academic Journal) › peer-review

22 Citations (Scopus)

Abstract

An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P=0.004) and sample two (P=0.015). In sample two there was a significant genotype times sex interaction (P=0.016), with the association of the A1 allele and reduced alcohol consumption significant in men only. This interaction was marginally significant (P=0.042) in a meta-analysis of combined data from both samples, and the main effect of genotype highly significant (P

Translated title of the contribution	Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers
Original language	English
Pages (from-to)	96 - 101
Number of pages	6
Journal	Pharmacogenomics Journal
Volume	5
DOIs	https://doi.org/10.1038/sj.tpj.6500294
Publication status	Published - Jan 2005

Bibliographical note

Publisher: Nature Publishing Group

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10.1038/sj.tpj.6500294

http://www.nature.com/tpj/journal/v5/n2/abs/6500294a.html

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title = "Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers",

abstract = "An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P=0.004) and sample two (P=0.015). In sample two there was a significant genotype times sex interaction (P=0.016), with the association of the A1 allele and reduced alcohol consumption significant in men only. This interaction was marginally significant (P=0.042) in a meta-analysis of combined data from both samples, and the main effect of genotype highly significant (P",

author = "MR Munafo and EC Johnstone and KI Welsh and RT Walton",

note = "Publisher: Nature Publishing Group",

year = "2005",

month = jan,

doi = "10.1038/sj.tpj.6500294",

language = "English",

volume = "5",

pages = "96 -- 101",

journal = "Pharmacogenomics Journal",

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T1 - Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers

AU - Munafo, MR

AU - Johnstone, EC

AU - Welsh, KI

AU - Walton, RT

N1 - Publisher: Nature Publishing Group

PY - 2005/1

Y1 - 2005/1

N2 - An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P=0.004) and sample two (P=0.015). In sample two there was a significant genotype times sex interaction (P=0.016), with the association of the A1 allele and reduced alcohol consumption significant in men only. This interaction was marginally significant (P=0.042) in a meta-analysis of combined data from both samples, and the main effect of genotype highly significant (P

AB - An association between the DRD2 Taq1A (C32806T) polymorphism and social alcohol consumption in the opposite direction to that reported for alcoholism has recently been reported in a male Finnish sample. We attempted to replicate these findings in two independent samples, and extend on previous work by including female participants. The DRD2 A1 allele was significantly associated with reduced alcohol consumption in sample one (P=0.004) and sample two (P=0.015). In sample two there was a significant genotype times sex interaction (P=0.016), with the association of the A1 allele and reduced alcohol consumption significant in men only. This interaction was marginally significant (P=0.042) in a meta-analysis of combined data from both samples, and the main effect of genotype highly significant (P

U2 - 10.1038/sj.tpj.6500294

DO - 10.1038/sj.tpj.6500294

M3 - Article (Academic Journal)

VL - 5

SP - 96

EP - 101

JO - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

SN - 1470-269X

ER -