Association of Markers of Non-Alcoholic Fatty Liver Disease with Cardiac Structure and Function in a General Population of Adolescents

Sumaiya Patel, Abigail Fraser

Research output: Contribution to journalArticle (Academic Journal)peer-review

31 Downloads (Pure)

Abstract

Background and Aims: Little evidence exists from general population studies examining the association of non-alcoholic fatty liver disease (NAFLD) with cardiac structure and function, independent of adiposity.

Methods: Cross-sectional study of a general population of adolescents (mean age 17 years). We estimated associations of 1. Blood-based markers of NAFLD: alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) (N = 1,440) 2. Ultrasound (USS) diagnosed NAFLD and shear velocity (N = 654) with echocardiography-based measures of cardiac structure and function.

Results: ALT, AST, GGT and shear velocity were positively associated with left ventricular mass index [LVMI (g/m2.7)],mean difference (95% confidence intervals(CI)) per 10U/L for blood-based markers and per m/sec for shear velocity: 0.56 (0.28, 0.83), 0.40 (0.02, 0.77), 0.59 (0.36, 0.81) and 0.61 (0.13, 1.09) when adjusting for age, sex, social class, pubertal status, smoking, and alcohol intake and with left a trial size index: 1.39% (0.66%, 2.13%), 1.28 (0.30, 2.28), 1.01 (0.43, 1.59) and 2.56 (1.21, 3.93) respectively. After additional adjustment for fat mass, only GGT remained associated with LVMI: 0.29 (0.09, 0.50). GGT and shear velocity were inversely associated with peak myocardial wall velocity in systole in confounder-adjusted models including fat mass. ALT, AST and GGT were positively associated with left ventricular diastolic diameter in age and sex-adjusted model, but associations attenuated in confounder-adjusted models. No associations between measures of NAFLD and relative wall thickness, mid wall fractional shortening, ejection fraction, E/e’, mitral E/A, and e’ were found and there was no difference in any measures of cardiac structure and function between adolescents with (N = 13) and without USS fatty liver (N = 641).

Conclusions: We found no robust evidence that markers of NAFLD are associated with cardiac structure or function independent of adiposity in a general adolescent population.
Original languageEnglish
Article number1091
Number of pages10
JournalJournal of Endocrinology, Diabetes and Obesity
Volume4
Issue number3
Early online date17 Sep 2016
Publication statusPublished - 17 Sep 2016

Fingerprint Dive into the research topics of 'Association of Markers of Non-Alcoholic Fatty Liver Disease with Cardiac Structure and Function in a General Population of Adolescents'. Together they form a unique fingerprint.

Cite this