Association of the DRD2 Taq1 polymorphism and alcoholism: A meta-analysis of case-control studies and evidence of publication bias

MR Munafo, IJ Matheson, J Flint

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

We investigated the association of the dopamine D2 receptor (DRD2) Taq1A polymorphism and alcoholism, using meta-analytic techniques, and specifically undertook an investigation of possible publication bias. Potential publication bias represents a genuine risk to the integrity of published research, but its impact has rarely been documented. We observed a small effect of the DRD2 Taq1A polymorphism on risk of alcoholism, indicating increased alcoholism in individuals possessing the A1 allele of the Taq1A polymorphism (OR=1.21, 95% CI 1.13–1.30, P
Translated title of the contributionAssociation of the DRD2 Taq1 polymorphism and alcoholism: A meta-analysis of case-control studies and evidence of publication bias
Original languageEnglish
Pages (from-to)454 - 461
Number of pages8
JournalMolecular Psychiatry
Volume12
Publication statusPublished - 2009

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