Associations among serum N-terminal procollagen type III concentration, urinary aldosterone-to-creatinine ratio, and ventricular remodeling in dogs with myxomatous mitral valve disease

Melanie J Hezzell, Adrian Boswood, Yu-Mei Chang, Walasinee Moonarmart, Jonathan Elliott

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Abstract

OBJECTIVE: To assess relationships among serum N-terminal procollagen type III concentration, urinary aldosterone-to-creatinine concentration ratio (UAC), and clinical variables in dogs with myxomatous mitral valve disease (MMVD) and healthy dogs.

ANIMALS: 162 dogs with MMVD and 24 healthy control dogs of comparable age and body weight.

PROCEDURES: Blood and urine samples were collected from each dog. Dogs with MMVD underwent echocardiography and ECG. Ventricular diameter measurements were normalized for body weight. Serum N-terminal procollagen type III and urinary aldosterone concentrations were measured via radioimmunoassay. Each dog was examined on 1 to 3 occasions. Examinations were repeated at approximately 6-month intervals.

RESULTS: Serum N-terminal procollagen type III concentration decreased with increasing severity of MMVD and was negatively associated with age and left ventricular end-diastolic and end-systolic diameters. The UAC increased with prior percentage change in left ventricular end-diastolic diameter per month, subsequent percentage change in left ventricular end-systolic diameter per month, and treatment with diuretics and was negatively associated with age. Both UAC and serum N-terminal procollagen type III concentration were higher in Cavalier King Charles Spaniels than in other breeds when other measured variables were controlled for.

CONCLUSIONS AND CLINICAL RELEVANCE: In dogs with MMVD, echocardiographic indicators of left ventricular remodeling appeared to be associated with a decrease in serum concentration of a marker of collagen type III turnover and an increase in urinary aldosterone concentration.

Original languageEnglish
Pages (from-to)1765-74
Number of pages10
JournalAmerican Journal of Veterinary Research
Volume73
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Aldosterone
  • Animals
  • Creatinine
  • Dog Diseases
  • Dogs
  • Female
  • Male
  • Mitral Valve Prolapse
  • Peptide Fragments
  • Procollagen
  • Ventricular Remodeling

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