Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme

Tamuno K Alfred; Yoav Ben-Shlomo; Rachel Cooper; Rebecca Hardy; Ian J Deary; Jane Elliott; Sarah E Harris; Mika Kivimaki; Meena Kumari; Chris Power; John M Starr; Diana Kuh; Ian N M Day; the HALCyon Study Team

doi:10.1371/journal.pone.0070045

Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme

Tamuno K Alfred
, Yoav Ben-Shlomo
, Rachel Cooper
, Rebecca Hardy
, Ian J Deary
, Jane Elliott
, Sarah E Harris
, Mika Kivimaki
, Meena Kumari
, Chris Power
, John M Starr
, Diana Kuh
, Ian N M Day
, the HALCyon Study Team

Research output: Contribution to journal › Article (Academic Journal) › peer-review

7 Citations (Scopus)

Abstract

The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.

Original language	English
Pages (from-to)	e70045
Journal	PLOS ONE
Volume	8
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0070045
Publication status	Published - 2013

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Alfred, T. K., Ben-Shlomo, Y., Cooper, R., Hardy, R., Deary, I. J., Elliott, J., Harris, S. E., Kivimaki, M., Kumari, M., Power, C., Starr, J. M., Kuh, D., Day, I. N. M., & the HALCyon Study Team (2013). Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme. PLOS ONE, 8(7), e70045. https://doi.org/10.1371/journal.pone.0070045

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title = "Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme",

abstract = "The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.",

author = "Alfred, \{Tamuno K\} and Yoav Ben-Shlomo and Rachel Cooper and Rebecca Hardy and Deary, \{Ian J\} and Jane Elliott and Harris, \{Sarah E\} and Mika Kivimaki and Meena Kumari and Chris Power and Starr, \{John M\} and Diana Kuh and Day, \{Ian N M\} and \{the HALCyon Study Team\}",

year = "2013",

doi = "10.1371/journal.pone.0070045",

language = "English",

volume = "8",

pages = "e70045",

journal = "PLOS ONE",

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Alfred, TK, Ben-Shlomo, Y, Cooper, R, Hardy, R, Deary, IJ, Elliott, J, Harris, SE, Kivimaki, M, Kumari, M, Power, C, Starr, JM, Kuh, D, Day, INM & the HALCyon Study Team 2013, 'Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme', PLOS ONE, vol. 8, no. 7, pp. e70045. https://doi.org/10.1371/journal.pone.0070045

TY - JOUR

T1 - Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes

T2 - The HALCyon Programme

AU - Alfred, Tamuno K

AU - Ben-Shlomo, Yoav

AU - Cooper, Rachel

AU - Hardy, Rebecca

AU - Deary, Ian J

AU - Elliott, Jane

AU - Harris, Sarah E

AU - Kivimaki, Mika

AU - Kumari, Meena

AU - Power, Chris

AU - Starr, John M

AU - Kuh, Diana

AU - Day, Ian N M

AU - the HALCyon Study Team

PY - 2013

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AB - The glucokinase regulatory protein encoded by GCKR plays an important role in glucose metabolism and a single nucleotide polymorphism (SNP) rs1260326 (P446L) in the gene has been associated with several age-related biomarkers, including triglycerides, glucose, insulin and apolipoproteins. However, associations between SNPs in the gene and other ageing phenotypes such as cognitive and physical capability have not been reported.

U2 - 10.1371/journal.pone.0070045

DO - 10.1371/journal.pone.0070045

M3 - Article (Academic Journal)

C2 - 23894584

SN - 1932-6203

VL - 8

SP - e70045

JO - PLOS ONE

JF - PLOS ONE

IS - 7

ER -

Associations between a Polymorphism in the Pleiotropic GCKR and Age-Related Phenotypes: The HALCyon Programme

Abstract

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