Associations between hair manganese levels and cognitive, language, and motor development in preschool children from Montevideo, Uruguay

Stephanie M Rink, Graciela Ardoino, Elena I Queirolo, Daniela Cicariello, Nelly Mañay, Katarzyna Kordas

Research output: Contribution to journalArticle (Academic Journal)peer-review

28 Citations (Scopus)

Abstract

Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 ± 0.74 and 10.1 ± 10.5 μg/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.
Original languageEnglish
Pages (from-to)46-54
Number of pages9
JournalArchives of Environmental and Occupational Health
Volume69
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Child Development
  • Child, Preschool
  • Cognition
  • Environmental Exposure
  • Female
  • Hair
  • Humans
  • Infant
  • Language Development
  • Male
  • Manganese
  • Neuropsychological Tests
  • Psychomotor Performance
  • Sex Factors
  • Uruguay

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